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Université de Fribourg

Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism

Filice, Federica ; Vörckel, Karl Jakob ; Sungur, Ayse Özge ; Wöhr, Markus ; Schwaller, Beat

In: Molecular Brain, 2016, vol. 9, p. 10

Background A reduction of the number of parvalbumin (PV)-immunoreactive (PV⁺) GABAergic interneurons or a decrease in PV immunoreactivity was reported in several mouse models of autism spectrum disorders (ASD). This includes Shank mutant mice, with SHANK being one of the most important gene families mutated in human ASD. Similar findings were obtained in heterozygous (PV+/-)...