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    Université de Fribourg

    Characterization and potential roles of calretinin in rodent spermatozoa

    Dressen, Cindy ; Schwaller, Beat ; Vegh, Grégory ; Leleux, Fabienne ; Gall, David ; Lebrun, Philippe ; Lybaert, Pascale

    In: Cell Calcium, 2018, vol. 74, p. 94–101

    Calretinin has been detected in various excitable cells but the presence and putative roles of such a calcium-binding protein has never been characterized in sperm.Epididymal spermatozoa were collected from C57Bl6 (wild-type, WT) or calretinin knockout (CR−/−) mice and Wistar rats. A specific staining for calretinin was detected by immunofluorescence in the principal piece of the...

    Université de Fribourg

    Subcellular structural plasticity caused by the absence of the fast Ca²⁺ buffer calbindin D-28k in recurrent collaterals of cerebellar Purkinje neurons

    Orduz, David ; Boom, Alain ; Gall, David ; Brion, Jean-Pierre ; Schiffmann, Serge N. ; Schwaller, Beat

    In: Frontiers in Cellular Neuroscience, 2014, vol. 8, p. 364

    Purkinje cells (PC) control spike timing of neighboring PC by their recurrent axon collaterals. These synapses underlie fast cerebellar oscillations and are characterized by a strong facilitation within a time window of <20 ms during paired-pulse protocols. PC express high levels of the fast Ca²⁺ buffer protein calbindin D-28k (CB). As expected from the absence of a fast Ca²⁺ buffer,...