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    Université de Fribourg

    Dynamic laser speckle imaging of cerebral blood flow

    Zakharov, Pavel ; Völker, A. C. ; Wyss, M. T. ; Haiss, F. ; Calcinaghi, N. ; Zunzunegui, C. ; Buck, Alfred ; Scheffold, Frank ; Weber, Bruno

    In: Optics Express, 2009, vol. 17, no. 16, p. 13904-13917

    Laser speckle imaging (LSI) based on the speckle contrast analysis is a simple and robust technique for imaging of heterogeneous dynamics. LSI finds frequent application for dynamical mapping of cerebral blood flow, as it features high spatial and temporal resolution. However, the quantitative interpretation of the acquired data is not straightforward for the common case of a speckle field formed...

    Université de Fribourg

    Improved in vivo two-photon imaging after blood replacement by perfluorocarbon

    Haiss, F. ; Jolivet, R. ; Wyss, M. T. ; Reichold, J. ; Ben Braham, Nasser ; Scheffold, Frank ; Krafft, M. P. ; Weber, B.

    In: The Journal of Physiology, 2009, vol. 587, p. 3153-3158

    Two-photon microscopy is a powerful method in biomedical research that allows functional and anatomical imaging at a subcellular resolution in vivo. The technique is seriously hampered by absorption and scattering of light by blood, which prevents imaging through large vessels. Here, we demonstrate in the rat cerebral cortex that blood replacement by perfluorocarbon emulsion, a compound also used...

    Université de Fribourg

    Optical imaging of the spatiotemporal dynamics of cerebral blood flow and oxidative metabolism in the rat barrel cortex

    Weber, B. ; Burger, C. ; Wyss, M. T. ; Schulthess, G. K. von ; Scheffold, Frank ; Buck, Alfred

    In: European Journal of Neuroscience, 2004, vol. 20, p. 2664-2670

    Oxidative metabolism and cerebral blood flow (CBF) are two of the most important measures in neuroimaging. However, results from concurrent imaging of the two with high spatial and temporal resolution have never been published. We used flavoprotein autofluorescence (AF) and laser speckle imaging (LSI) in the anaesthetized rat to map oxidative metabolism and CBF in response to single vibrissa...