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Université de Fribourg

Taylor dispersion of inorganic nanoparticles and comparison to dynamic light scattering and transmission electron microscopy

A.Urban, Dominic ; M.Milosevic, Ana ; Bossert, David ; Crippa, Federica ; L.Moore, Thomas ; Geers, Christoph ; Balog, Sandor ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Colloid and Interface Science Communications, 2018, vol. 22, p. 29–33

Taylor dispersion analysis (TDA) is an analytical method that has so far mainly been utilized to determine the diffusion coefficient of small molecules, and proteins. Due to increasing interest in nanoscience, some research has been done on the applicability of TDA towards characterizing nanoparticles. This work aims to expand this knowledge and give insight into the range for which TDA can...

Université de Fribourg

Translocation of gold nanoparticles across the lung epithelial tissue barrier: Combining in vitro and in silico methods to substitute in vivo experiments

Bachler, Gerald ; Losert, Sabrina ; Umehara, Yuki ; Goetz, Natalie von ; Rodriguez-Lorenzo, Laura ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Hungerbuehler, Konrad

In: Particle and Fibre Toxicology, 2015, vol. 12, no. 1, p. 18

The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into the systemic circulation. Thus great efforts are currently being made to determine adverse health effects associated with inhalation of NPs. However, to date very little is known about factors that determine the pulmonary translocation of NPs and their subsequent distribution to secondary...

Université de Fribourg

Dynamic depolarized light scattering of small round plasmonic nanoparticles: When imperfection is only perfect

Balog, Sandor ; Rodriguez-Lorenzo, Laura ; Monnier, Christophe A. ; Michen, Benjamin ; Obiols-Rabasa, Marc ; Casal-Dujat, Lucia ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke ; Schurtenberger, Peter

In: The Journal of Physical Chemistry C, 2014, vol. 118, no. 31, p. 17968–17974

Although small round gold nanoparticles (Au NPs) possess only a small degree of shape anisotropy, they support localized surface plasmon resonances and exhibit intrinsic optical anisotropy. These inherent features promote depolarized light scattering, whose temporal fluctuations carry information about rotational Brownian dynamics, and thus can be used to describe the size distribution of...

Université de Fribourg

Characterizing nanoparticles in complex biological media and physiological fluids with depolarized dynamic light scattering

Balog, Sandor ; Rodriguez-Lorenzo, Laura ; Monnier, Christophe A. ; Obiols-Rabas, Marc ; Rothen-Rutishauser, Barbara ; Schurtenberger, Peter ; Petri-Fink, Alke

In: Nanoscale, 2015, p. -

Light scattering is one of the few techniques available to adequately characterize suspended nanoparticles (NPs) in real time and in situ. However, when it comes to NPs in multicomponent and optically complex aqueous matrices – such as biological media and physiological fluids – light scattering suffers from lack of selectivity, as distinguishing the relevant optical signals from the...

Université de Fribourg

Use of EpiAlveolar lung model to predict fibrotic potential of multiwalled carbon nanotubes

Barosova, Hana ; Maione, Anna G. ; Septiadi, Dedy ; Sharma, Monita ; Haeni, Laetitia ; Balog, Sandor ; O’Connell, Olivia ; Jackson, George R. ; Brown, David ; Clippinger, Amy J. ; Hayden, Patrick ; Petri-Fink, Alke ; Stone, Vicki ; Rothen-Rutishauser, Barbara

In: ACS Nano, 2020, vol. 14, no. 4, p. 3941–3956

Expansion in production and commercial use of nanomaterials increases the potential human exposure during the lifecycle of these materials (production, use, and disposal). Inhalation is a primary route of exposure to nanomaterials; therefore it is critical to assess their potential respiratory hazard. Herein, we developed a three-dimensional alveolar model (EpiAlveolar) consisting of human...

Université de Fribourg

An in vitro lung system to assess the proinflammatory hazard of carbon nanotube aerosols

Barosova, Hana ; Karakocak, Bedia Begum ; Septiadi, Dedy ; Petri-Fink, Alke ; Stone, Vicki ; Rothen-Rutishauser, Barbara

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 15, p. 5335

In vitro three-dimensional (3D) lung cell models have been thoroughly investigated in recent years and provide a reliable tool to assess the hazard associated with nanomaterials (NMs) released into the air. In this study, a 3D lung co-culture model was optimized to assess the hazard potential of multiwalled carbon nanotubes (MWCNTs), which is known to provoke inflammation and fibrosis,...

Université de Fribourg

Multicellular human alveolar model composed of epithelial cells and primary immune cells for hazard assessment

Barosova, Hana ; Drasler, Barbara ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: JoVE (Journal of Visualized Experiments), 2020, no. 159, p. e61090

A human alveolar cell coculture model is described here for simulation of the alveolar epithelial tissue barrier composed of alveolar epithelial type II cells and two types of immune cells (i.e., human monocyte-derived macrophages [MDMs] and dendritic cells [MDDCs]). A protocol for assembling the multicellular model is provided. Alveolar epithelial cells (A549 cell line) are grown and...

Université de Fribourg

Biological response of an in vitro human 3D lung cell model exposed to brake wear debris varies based on brake pad formulation

Barosova, Hana ; Chortarea, Savvina ; Peikertova, Pavlina ; J. D. Clift, Martin ; Petri-Fink, Alke ; Kukutschova, Jana ; Rothen-Rutishauser, Barbara

In: Archives of Toxicology, 2018, vol. 92, no. 7, p. 2339–2351

Wear particles from automotive friction brake pads of various sizes, morphology, and chemical composition are significant contributors towards particulate matter. Knowledge concerning the potential adverse effects following inhalation exposure to brake wear debris is limited. Our aim was, therefore, to generate brake wear particles released from commercial low-metallic and non-asbestos organic...

Université de Fribourg

Mimicking the chemistry of natural eumelanin synthesis: the ke sequence in polypeptides and in proteins allows for a specific control of nanosized functional polydopamine formation

Bergtold, Camille ; Hauser, Daniel ; Alain Chaumont ; El Yakhlifi, Salima ; Mateescu, Mihaela ; Meyer, Florent ; Metz-Boutigue, Marie-Hélène ; Benoît Frisch ; Schaaf, Pierre ; Ihiawakrim, Dris ; Ersen, Ovidiu ; Monnier, Christophe A. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Ball, Vincent

In: Biomacromolecules, 2018, vol. 19, no. 9, p. 3693–3704

The oxidation of dopamine and of other catecholamines leads to the formation of conformal films on the surface of all known materials and to the formation of a precipitate in solution. In some cases, it has been shown that the addition of additives in the dopamine solution, like certain surfactants or polymers, polyelectrolytes, and certain proteins, allows to get polydopamine nanoparticles...