Université de Fribourg

Modulation of mgrB gene expression as a source of colistin resistance in Klebsiella oxytoca

Jayol, Aurélie ; Poirel, Laurent ; Villegas, Maria-Virginia ; Nordmann, Patrice

In: International Journal of Antimicrobial Agents, 2015, vol. 46, no. 1, p. 108–110

Gene modifications in the PmrAB and PhoPQ two-component regulatory systems, as well as inactivation of the mgrB gene, are known to be causes of colistin resistance in Klebsiella pneumoniae. The objective of this study was to characterise the mechanism involved in colistin resistance in a Klebsiella oxytoca isolate. A K. oxytoca clinical isolate showing resistance to colistin was recovered in...

Université de Fribourg

The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae

Poirel, Laurent ; Jayol, Aurélie ; Bontron, Séverine ; Villegas, Maria-Virginia ; Ozdamar, Melda ; Türkoglu, Salih ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 1, p. 75-80

Objectives Alterations in the PhoPQ two-component regulatory system may be associated with colistin resistance in Klebsiella pneumoniae. MgrB is a small transmembrane protein produced upon activation of the PhoPQ signalling system, and acts as a negative regulator on this system. We investigated the role of the MgrB protein as a source of colistin resistance in a series of K. pneumoniae.Methods...