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Cross-border emergence of Escherichia coli producing the carbapenemase NDM-5 in Switzerland and Germany

Chakraborty, Trinad ; Sadek, Mustafa ; Yao, Yancheng ; Imirzalioglu, Can ; Stephan, Roger ; Poirel, Laurent ; Nordmann, Patrice

In: Journal of Clinical Microbiology, 2020, p. -

A series of clinical NDM-5-producing E. coli isolates obtained from two surveillance networks of carbapenem-producing Enterobacterales from 2018-2019, namely Switzerland (NARA) and Germany (SurvCARE), were analyzed. The 33 NDM-5- producing E. coli isolates were highly resistant to β-lactams including the novel ß- lactam/ß-lactamase inhibitor combinations (ceftazidime/avibactam, ...

Full genome sequence of pT3, a multiresistant plasmid carrying the mcr-3.5 colistin resistance gene, recovered from an extended-spectrum-β-lactamase-producing Escherichia coli isolate from crickets sold as food

Zurfluh, Katrin ; Stevens, Marc J. A. ; Bucher, Melissa ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Microbiology Resource Announcements, 2019/8/29/e00647-19, /mra/8/29/MRA.00647-19.atom

Here, we sequenced multidrug resistance plasmid pT3, which encodes mcr-3.5 and other resistance genes. The cooccurrence of mcr genes and other resistance genes on a single plasmid is of concern.

First report of an mcr-1-harboring Salmonella enterica subsp. enterica serotype 4,5,12:i:- strain isolated from blood of a patient in Switzerland

M.Carroll, Laura ; Zurfluh, Katrin ; Jang, Hyein ; Gopinath, Gopal ; Nüesch-Inderbinen, Magdalena ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger ; Guldimann, Claudia

In: International Journal of Antimicrobial Agents, 2018, vol. 52, no. 5, p. 740–741

Rapid polymyxin NP test for the detection of polymyxin resistance mediated by the MCR-1/MCR-2 genes

Poirel, Laurent ; Larpin, Yu ; Dobias, Jan ; Stephan, Roger ; Decousser, Jean-Winoc ; Madec, Jean-Yves ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2018, vol. 90, no. 1, p. 7–10

The Rapid Polymyxin NP test has been recently developed to rapidly detect polymyxin resistance in Enterobacteriaceae. Here we evaluated this test for detecting MCR- 1/MCR-2-producing Enterobacteriaceae using a collection of 70 non-redundant strains either recovered from the environment, animals, or humans. Sensitivity and specificity were found to be 100%.

Key features of mcr-1-bearing plasmids from Escherichia coli isolated from humans and food

Zurfluh, Katrin ; Nüesch-Inderbinen, Magdalena ; Klumpp, Jochen ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Antimicrobial Resistance & Infection Control, 2017, vol. 6, p. 91

Mcr-1-harboring Enterobacteriaceae are reported worldwide since their first discovery in 2015. However, a limited number of studies are available that compared full-length plasmid sequences of human and animal origins.

The carbapenemase threat in the animal world: the wrong culprit

Poirel, Laurent ; Stephan, Roger ; Perreten, Vincent ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2014, vol. 69, no. 7, p. 2007-2008

Screening for fecal carriage of MCR-producing Enterobacteriaceae in healthy humans and primary care patients

Zurfluh, Katrin ; Stephan, Roger ; Widmer, Andreas ; Poirel, Laurent ; Nordmann, Patrice ; Nüesch, Hans-Jakob ; Hächler, Herbert ; Nüesch-Inderbinen, Magdalena

In: Antimicrobial Resistance & Infection Control, 2017, vol. 6, p. 28

The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene has the potential to restore antibiotic susceptibility in all bacteria carrying the gene.Methods: We have constructed a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) that selectively inhibits...

Features of the mcr-1 cassette related to colistin resistance

Zurfluh, Katrin ; Kieffer, Nicolas ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 10, p. 6438–6439

Occurrence and features of chromosomally encoded carbapenemases in Gram-negative bacteria in farm animals sampled at slaughterhouse level

Zurfluh, Katrin ; Hindermann, D. ; Nüesch-Inderbinen, Magdalena ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Archives Suisses de Médecine Vétérinaire, 2016, vol. 158, no. 6, p. 457-460

Occurrence of the plasmid-borne mcr-1 colistin resistance gene in extended-spectrum-β-lactamase-producing Enterobacteriaceae in river water and imported vegetable samples in Switzerland

Zurfuh, Katrin ; Poirel, Laurent ; Nordmann, Patrice ; Nüesch-Inderbinen, Magdalena ; Hächler, Herbert ; Stephan, Roger

In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 4, p. 2594–2595