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Cellular shuttles: monocytes/macrophages exhibit transendothelial transport of nanoparticles under physiological flow

Moore, Thomas L. ; Hauser, Daniel ; Gruber, Thomas ; Rothen-Rutishauser, Barbara ; Lattuada, Marco ; Petri-Fink, Alke ; Lyck, Ruth

In: ACS Applied Materials & Interfaces, 2017, vol. 9, no. 22, p. 18501–18511

A major hurdle in the development of biomedical nanoparticles (NP) is understanding how they interact with complex biological systems and navigate biological barriers to arrive at pathological targets. It is becoming increasingly evident that merely controlling particle physicochemical properties may not be sufficient to mediate particle biodistribution in dynamic environments. Thus,...