In: Frontiers in Molecular Neuroscience, 2019, vol. 12, p. -
Aquatic vertebrates possess diverse types of sensory cells in their skin to detect stimuli in the water. In the adult zebrafish, a common model organism, the presence of such cells in fins has only rarely been studied. Here, we identified scattered serotonin (5-HT)-positive cells in the epidermis of the caudal fin. These cells were distinct from keratinocytes as revealed by their low...
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In: Angiogenesis, 2013, vol. 16, no. 4, p. 921-937
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In: Angiogenesis, 2009, vol. 12, no. 2, p. 113-123
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In: European Heart Journal, 2010, vol. 31, no. 14, p. 1792-1801
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In: PLOS ONE, 2016, vol. 11, no. 3, p. e0149281
Background: Researchers evaluating angiomodulating compounds as a part of scientific projects or pre-clinical studies are often confronted with limitations of applied animal models. The rough and insufficient early-stage compound assessment without reliable quantification of the vascular response counts, at least partially, to the low transition rate to clinics. Objective: To establish an...
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In: Angiogenesis, 2013, p. 1-17
Notch is an intercellular signaling pathway related mainly to sprouting neo- angiogenesis. The objective of our study was to evaluate the angiogenic mechanisms involved in the vascular augmentation (sprouting/intussusception) after Notch inhibition within perfused vascular beds using the chick area vasculosa and MxCreNotch1(lox/lox) mice. In vivo monitoring combined with morphological ...
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In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2011, vol. 31, p. 2836-2844
Objective—The concept of vascular pruning, the “cuting-off” of vessels, is gaining importance due to expansion of angio-modulating therapies. The proangiogenic effects of vascular endothelial growth factor (VEGF) are broadly described, but the mechanisms of structural alterations by its downregulation are not known.Methods and Results—VEGF165-releasing hydrogels were applied onto the...
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In: Clinical Anatomy, 2011, p. -
Anatomical variability within the autonomic nervous system has long been accepted. This study evaluated the anatomical variability of the cervicothoracic ganglion (CTG) according to its form and, in addition, provided precise measurements between the CTG and the anterior tubercle of the transverse process of the sixth cervical vertebra (C6TP), the first costovertebral articulation, and the...
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In: Journal of Shoulder and Elbow Surgery, 2011, vol. 21, no. 5, p. 604-611
Objective: To investigate the technical feasibility of harvesting a vascularized bone graft from the acromion pedicled on the acromial branch.Background: Complex fractures of the proximal humerus may result in partial or total avascular necrosis of the head fragment. Treatment of avascular necrosis of the humeral head is dependent upon the stage of disease as well as the dimension and...
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In: Molecular Cancer Therapeutics, 2011, vol. 10, no. 6, p. 1007-1017
Sorafenib targets the Raf/mitogen activated protein kinase, VEGF and PDGF pathways and prolongs survival patients in advanced hepatocellular carcinoma (HCC). Everolimus inhibits the mammalian target of rapamycin, a kinase overactive in HCC. To investigate whether the antitumor effects of these agents are additive, we compared a combined and sequential treatment regimen of everolimus and...
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