In: Molecular Ecology, 2012, vol. 21, no. 20, p. 4931–4941
The genomic basis of adaptation to novel environments is a fundamental problem in evolutionary biology that has gained additional importance in the light of the recent global change discussion. Here, we combined laboratory natural selection (experimental evolution) in Drosophila melanogaster with genome‐wide next generation sequencing of DNA pools (Pool‐Seq) to identify alleles that are...
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In: Journal of Evolutionary Biology, 2019, vol. 32, no. 5, p. 425–437
Experimental evolution (EE) is a powerful tool for addressing how environmental factors influence life‐history evolution. While in nature different selection pressures experienced across the lifespan shape life histories, EE studies typically apply selection pressures one at a time. Here, we assess the consequences of adaptation to three different developmental diets in combination with...
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In: Ecology and Evolution, 2017, vol. 7, no. 11, p. 3796–3807
A fundamental question in life‐history evolution is how organisms cope with fluctuating environments, including variation between stressful and benign conditions. For short‐ lived organisms, environments commonly vary between generations. Using a novel experimental design, we exposed wild‐derived Drosophila melanogaster to three different selection regimes: one where generations...
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In: Molecular Ecology, 2019, vol. 28, no. 6, p. 1263–1282
Chromosomal inversions, structural mutations that reverse a segment of a chromosome, cause suppression of recombination in the heterozygous state. Several studies have shown that inversion polymorphisms can form clines or fluctuate predictably in frequency over seasonal time spans. These observations prompted the hypothesis that chromosomal rearrangements might be subject to spatially and/or ...
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In: Nature Education Knowledge, 2010, vol. 1, no. 12, p. 1-6
This case study highlights the general issues raised earlier. First, that maximum lifespan is not an easily obtainable metric. Specifically, it is unambiguous in the sense that once the last animal dies, it is most definitely dead. But to estimate the variance in maximum lifespan, many replicate populations would need to be followed for each treatment group (with each replicate providing a single...
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In: Developmental Cell, 2019, vol. 50, no. 6, p. 780-792.e7
Size trade-offs of visual versus olfactory organs is a pervasive feature of animal evolution. This could result from genetic or functional constraints. We demonstrate that head sensory organ size trade-offs in Drosophila are genetically encoded and arise through differential subdivision of the head primordium into visual versus non- visual fields. We discover that changes in the temporal...
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In: Scientific Reports, 2018, vol. 8, no. 1, p. 2030
In response to adverse environmental conditions many organisms from nematodes to mammals deploy a dormancy strategy, causing states of developmental or reproductive arrest that enhance somatic maintenance and survival ability at the expense of growth or reproduction. Dormancy regulation has been studied in C. elegans and in several insects, but how neurosensory mechanisms act to relay ...
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In: Current Opinion in Insect Science, 2017, vol. 23, p. 118–122
Manipulating amino acid (AA) intake in Drosophila can profoundly affect lifespan and reproduction. Remarkably, AA manipulation can uncouple the commonly observed trade-off between these traits. This finding seems to challenge the idea that this trade- off is due to competitive resource allocation, but here we argue that this view might be too simplistic. We also discuss the mechanisms of the...
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In: Mechanisms of Ageing and Development, 2004, vol. 125(3), p. 155
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In: Journal of Theoretical Biology, 2001, vol. 212, no. 3, p. 345-354
To date, only a few studies have focused on the effects of sex on population dynamics. Previous models have typically found that sexual reproduction dampens population fluctuations. Although asexual and sexual reproduction are just the two endpoints along a continuum of varying rates of sex, previous work has ignored the effects of intermediate degrees of sex on population dynamics. Here we study...
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