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Université de Fribourg

Total energy expenditure assessed by doubly labeled water technique and estimates of physical activity in Mauritian children: analysis by gender and ethnicity

Ramuth, Harris ; Schutz, Yves ; Calonne, Julie ; Joonas, Noorjehan ; Dulloo, Abdul G.

In: European Journal of Clinical Nutrition, 2020, vol. 74, no. 3, p. 445–453

In the tropical island of Mauritius, the rise in obesity has accelerated in the past decades, and could be contributed by low physical activity and increased sedentary behavior. The study objectives were to generate the first dataset of total energy expenditure (TEE), to estimate physical activity in Mauritian children, and to explore differences due to gender and ethnicity.Subjects/methods:...

Université de Fribourg

Low 24-hour core body temperature as a thrifty metabolic trait driving catch-up fat during weight regain after caloric restriction

Calonne, Julie ; Arsenijevic, Denis ; Scerri, Isabelle ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre ; Dulloo, Abdul G.

In: American Journal of Physiology-Endocrinology and Metabolism, 2019, vol. 317, no. 4, p. E699–E709

The recovery of body weight after substantial weight loss or growth retardation is often characterized by a disproportionately higher rate of fat mass vs. lean mass recovery, with this phenomenon of “preferential catch-up fat” being contributed by energy conservation (thrifty) metabolism. To test the hypothesis that a low core body temperature (Tc) constitutes a thrifty metabolic trait...

Université de Fribourg

Assessment of the dose–response relationship between meal protein content and postprandial thermogenesis: effect of sex and the oral contraceptive pill

Duhita, Maharani R. ; Schutz, Yves ; Montani, Jean-Pierre ; Dulloo, Abdul G. ; Miles-Chan, Jennifer L.

In: Nutrients, 2019, vol. 11, no. 7, p. 1599

Implementation of efficacious dietary interventions to regulate energy balance requires understanding of the determinants of individual response. To date, information regarding individual variability in response to elevated meal protein content is lacking. This study investigates whether sex and/or oral contraceptive pill (OCP) use play a role in the response to elevated meal protein in 21...

Université de Fribourg

Reduced skeletal muscle protein turnover and thyroid hormone metabolism in adaptive thermogenesis that facilitates body fat recovery during weight regain

Calonne, Julie ; Isacco, Laurie ; Miles-Chan, Jennifer ; Arsenijevic, Denis ; Montani, Jean-Pierre ; Guillet, Christelle ; Boirie, Yves ; Dulloo, Abdul G.

In: Frontiers in Endocrinology, 2019, vol. 10, p. -

Objective: The recovery of body composition after weight loss is characterized by an accelerated rate of fat recovery (preferential catch-up fat) resulting partly from an adaptive suppression of thermogenesis. Although the skeletal muscle has been implicated as an effector site for such thrifty (energy conservation) metabolism driving catch-up fat, the underlying mechanisms remain to be...

Université de Fribourg

The contribution of Swiss scientists to the assessment of energy metabolism

Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G.

In: European Journal of Clinical Nutrition, 2018, vol. 72, no. 5, p. 665–679

Although Switzerland is considered a small country, it has its share in discoveries, inventions and developments for the assessment of energy metabolism. This includes seminal contributions to respiratory and metabolic physiology and to devices for measuring energy expenditure by direct and indirect calorimetry in vivo in humans and small animals (as well as in vitro in organs/tissues), for...

Université de Fribourg

Collateral fattening in body composition autoregulation: its determinants and significance for obesity predisposition

Dulloo, Abdul G. ; Miles-Chan, Jennifer L. ; Schutz, Yves

In: European Journal of Clinical Nutrition, 2018, vol. 72, no. 5, p. 657–664

Collateral fattening refers to the process whereby excess fat is deposited as a result of the body’s attempt to counter a deficit in lean mass through overeating. Its demonstration and significance to weight regulation and obesity can be traced to work on energy budget strategies in growing mammals and birds, and to men recovering from experimental starvation. The cardinal features of...

Université de Fribourg

Posture allocation revisited: breaking the sedentary threshold of energy expenditure for obesity management

Miles-Chan, Jennifer L. ; Dulloo, Abdul G.

In: Frontiers in Physiology, 2017, vol. 8, p. -

There is increasing recognition that low-intensity physical activities of daily life play an important role in achieving energy balance and that their societal erosion through substitution with sedentary (mostly sitting) behaviours, whether occupational or for leisure, impact importantly on the obesity epidemic. This has generated considerable interest for better monitoring, characterizing...

Université de Fribourg

Cardiovascular responses to sugary drinks in humans: galactose presents milder cardiac effects than glucose or fructose

Charrière, Nathalie ; Loonam, Cathriona ; Montani, Jean-Pierre ; Dulloo, Abdul G. ; Grasser, Erik K.

In: European Journal of Nutrition, 2017, vol. 56, no. 6, p. 2105–2113

PurposeThere is increasing interest into the potentially beneficial effects of galactose for obesity and type 2 diabetes management as it is a low-glycemic sugar reported to increase satiety and fat mobilization. However, fructose is also a low-glycemic sugar but with greater blood pressure elevation effects than after glucose ingestion. Therefore, we investigated here the extent to which the...

Université de Fribourg

Oral contraceptive pill alters acute dietary protein‐induced thermogenesis in young women

Duhita, Maharani Retna ; Schutz, Yves ; Montani, Jean-Pierre ; Dulloo, Abdul G. ; Miles-Chan, Jennifer L.

In: Obesity, 2017, vol. 25, no. 9, p. 1482–1485

Objective: There is much interest in the role of dietary protein for weight control. However, there remains a need to characterize individual determinants of the thermogenic effects of protein. This study aimed to investigate the influence of menstrual cycle phase and the combined, monophasic oral contraceptive pill on the thermogenic response to a standardized high-protein (HP) versus...

Université de Fribourg

Issues in continuous 24-H core body temperature monitoring in humans using an ingestible capsule telemetric sensor

Monnard, Cathriona R. ; Fares, Elie-Jacques ; Calonne, Julie ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre ; Durrer, Dominique ; Schutz, Yves ; Dulloo, Abdul G.

In: Frontiers in Endocrinology, 2017, vol. 8, p. -

Background: There is increasing interest in the use of pill-sized ingestible capsule telemetric sensors for assessing core body temperature (Tc) as a potential indicator of variability in metabolic efficiency and thrifty metabolic traits. The aim of this study was to investigate the feasibility and accuracy of measuring Tc using the CorTemp® system.Methods: Tc was measured over an average of 20...