Université de Fribourg

Brain networks modulated by subthalamic nucleus deep brain stimulation

Accolla, Ettore A. ; Ruiz, Maria Herrojo ; Horn, Andreas ; Schneider, Gerd-Helge ; Schmitz-Hübsch, Tanja ; Draganski, Bogdan ; Kühn, Andrea A.

In: Brain, 2016, vol. 139, no. 9, p. 2503–2515

Deep brain stimulation of the subthalamic nucleus is an established treatment for the motor symptoms of Parkinson’s disease. Given the frequent occurrence of stimulation- induced affective and cognitive adverse effects, a better understanding about the role of the subthalamic nucleus in non-motor functions is needed. The main goal of this study is to characterize anatomical circuits...

Université de Fribourg

Sustained enhancements in inhibitory control depend primarily on the reinforcement of fronto-basal anatomical connectivity

Chavan, Camille ; Mouthon, Michael ; Simone, Marie ; Hoogewoud, tHenri-Marcel ; Draganski, Bogdan ; Zwaag, Wietske van der ; Spierer, Lucas

In: Brain Structure and Function, 2017, vol. 222, no. 1, p. 635–643

What are the neurophysiological determinants of sustained supra-normal inhibitory control performance? We addressed this question by coupling multimodal neuroimaging and behavioral investigations of experts in fencing who underwent more than 20,000 h of inhibitory control training over 15 years. The superior control of the experts manifested behaviorally as a speeding-up of inhibition...

Université de Fribourg

Differential patterns of functional and structural plasticity within and between inferior frontal gyri support training-induced improvements in inhibitory control proficiency

Chavan, Camille F. ; Mouthon, Michael ; Draganski, Bogdan ; Zwaag, Wietske van der ; Spierer, Lucas

In: Human Brain Mapping, 2015, vol. 36, no. 7, p. 2527–2543

Ample evidence indicates that inhibitory control (IC), a key executive component referring to the ability to suppress cognitive or motor processes, relies on a right-lateralized fronto-basal brain network. However, whether and how IC can be improved with training and the underlying neuroplastic mechanisms remains largely unresolved. We used functional and structural magnetic resonance imaging to...