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Université de Fribourg

Lack of Calbindin-D28k alters response of the murine circadian clock to light

Stadler, Frédéric ; Schmutz, Isabelle ; Schwaller, Beat ; Albrecht, Urs

In: Chronobiology International, 2010, vol. 27, no. 1, p. 68-82

A strong stimulus adjusting the circadian clock to the prevailing light-dark cycle is light. However, the circadian clock is reset by light only at specific times of the day. The mechanisms mediating such gating of light input to the CNS are not well understood. There is evidence that Ca²⁺ ions play an important role in intracellular signaling mechanisms, including signaling cascades...