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CD81-induced behavioural changes during chronic cocaine administration: in vivo gene delivery with regulatable lentivirus

Bahi, Amine ; Boyer, Frederic ; Kafri, Tal ; Dreyer, Jean-Luc

In: European Journal of Neuroscience, 2004, vol. 19, p. 1621-1633

CD81, a tetraspanin transmembrane protein involved in cell adhesion, is up-regulated in the mesolimbic dopaminergic pathway 24 h following acute administration of high doses of cocaine [Brenz-Verca et al., (2001) Mol. Cell. Neurosci., 17, 303-316]. Further evidence consecutive with this observation and based on microarray analysis are presented here. In addition, a regulatable lentivirus was...