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Université de Fribourg

Lock-in thermography as a rapid and reproducible thermal characterization method for magnetic nanoparticles

Lemal, Philipp ; Geers, Christoph ; Monnier, Christophe A. ; Crippa, Federica ; Daum, Leopold ; Urban, Dominic A. ; Rothen-Rutishauser, Barbara ; Bonmarin, Mathias ; Petri-Fink, Alke

In: Journal of Magnetism and Magnetic Materials, 2017, vol. 427, p. 206–211

Lock-in thermography (LIT) is a sensitive imaging technique generally used in engineering and materials science (e.g. detecting defects in composite materials). However, it has recently been expanded for investigating the heating power of nanomaterials, such as superparamagnetic iron oxide nanoparticles (SPIONs). Here we implement LIT as a rapid and reproducible method that can evaluate the...

Université de Fribourg

Assumption-free morphological quantification of single anisotropic nanoparticles and aggregates

Vanhecke, Dimitri ; Rodríguez-Lorenzo, Laura ; Kinnear, Calum ; Durantie, Estelle ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Nanoscale, 2017, vol. 9, no. 15, p. 4918–4927

Characterizing the morphometric parameters of noble metal nanoparticles for sensing and catalysis is a persistent challenge due to their small size and complex shape. Herein, we present an approach to determine the volume, surface area, and curvature of non-symmetric anisotropic nanoparticles using electron tomography and design- based stereology without the use of segmentation tools or...

Université de Fribourg

Organometallic cobalamin anticancer derivatives for targeted prodrug delivery via transcobalamin-mediated uptake

Rossier, Jeremie ; Hauser, Daniel ; Kottelat, Emmanuel ; Rothen-Rutishauser, Barbara ; Zobi, Fabio

In: Dalton Transactions, 2017, vol. 46, no. 7, p. 2159–2164

Herein we report the synthesis of new water-soluble vitamin B12 prodrugs bearing metal complexes at the β-upper side of the cobalt center. A total of three derivatives with the general design {Co–C[triple bond, length as m-dash]C-bpy–M}, where M represents a cytotoxic metal complex, were prepared and tested for their cytotoxicity against MCF-7 breast cancer cells. The choice of the metal...

Université de Fribourg

Elucidating the potential biological impact of cellulose nanocrystals

Camarero-Espinosa, Sandra ; Endes, Carola ; Mueller, Silvana ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Weder, Christoph ; Clift, Martin James David ; Foster, E. Johan

In: Fibers, 2016, vol. 4, no. 3, p. 21

Cellulose nanocrystals exhibit an interesting combination of mechanical properties and physical characteristics, which make them potentially useful for a wide range of consumer applications. However, as the usage of these bio-based nanofibers increases, a greater understanding of human exposure addressing their potential health issues should be gained. The aim of this perspective is to...

Université de Fribourg

Decoupling the shape parameter to assess gold nanorod uptake by mammalian cells

Kinnear, Calum ; Rodriguez-Lorenzo, Laura ; Clift, M. J. D. ; Goris, B. ; Bals, S. ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Nanoscale, 2016, vol. 8, no. 36, p. 16416–16426

The impact of nanoparticles (NPs) upon biological systems can be fundamentally associated with their physicochemical parameters. A further often-stated tenet is the importance of NP shape on rates of endocytosis. However, given the convoluted parameters concerning the NP–cell interaction, it is experimentally challenging to attribute any findings to shape alone. Herein we demonstrate that...

Université de Fribourg

Combined exposure of diesel exhaust particles and respirable Soufrière Hills volcanic ash causes a (pro-)inflammatory response in an in vitro multicellular epithelial tissue barrier model

Tomašek, Ines ; Horwell, Claire J. ; Damby, David E. ; Barošová, Hana ; Geers, Christoph ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Clift, Martin J. D.

In: Particle and Fibre Toxicology, 2016, vol. 13, p. 67

There are justifiable health concerns regarding the potential adverse effects associated with human exposure to volcanic ash (VA) particles, especially when considering communities living in urban areas already exposed to heightened air pollution. The aim of this study was, therefore, to gain an imperative, first understanding of the biological impacts of respirable VA when exposed...

Université de Fribourg

Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms

Steiner, Sandro ; Bisig, Christoph ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Archives of Toxicology, 2016, p. 1–13

Diesel engine emissions are among the most prevalent anthropogenic pollutants worldwide, and with the growing popularity of diesel-fueled engines in the private transportation sector, they are becoming increasingly widespread in densely populated urban regions. However, a large number of toxicological studies clearly show that diesel engine emissions profoundly affect human health. Thus the...

Université de Fribourg

Engineered nanomaterials: toward effective safety management in research laboratories

Groso, Amela ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Hofmann, Heinrich ; Meyer, Thierry

In: Journal of Nanobiotechnology, 2016, vol. 14, p. 21

It is still unknown which types of nanomaterials and associated doses represent an actual danger to humans and environment. Meanwhile, there is consensus on applying the precautionary principle to these novel materials until more information is available. To deal with the rapid evolution of research, including the fast turnover of collaborators, a user-friendly and easy-to-apply risk...

Université de Fribourg

Distribution of silica-coated silver/gold nanostars in soft- and hardwood applying SERS-based imaging

Geers, Christoph ; Rodríguez-Lorenzo, Laura ; Placencia Peña, M. I. ; Brodard, Pierre ; Volkmer, T. ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Langmuir, 2016, vol. 32, no. 1, p. 274–283

Nanoparticles (NPs) in aqueous suspension have just begun to be exploited for the preservative treatment of wood. However, at present, there is very little information available on the distribution of NPs in wood after impregnation, due to associated analytical challenges. In this study, we present the detection of model NPs in softwood and hardwood by surface-enhanced Raman spectroscopy (SERS)....