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Université de Fribourg

Complexation and protonation behaviour of chiral tetradentate polypyridines derived from α-Pinene

Düggeli, Mathias ; Schläpfer, Carl-Willhelm (Dir.) ; Zelewsky, Alexander von (Codir.) ; Belser, Peter (Codir.) ; Stoeckli-Evans, Helen (Codir.)

Thèse de doctorat : Université de Fribourg, 2002 ; Nr. 1382.

Im Rahmen der vorliegenden Arbeit wurden neue enantiomerenreine 5’- und 6’- substituierte, mit Pinen annellierte Bipyridin- (Pinen-bpy Derivate) und N-Pyridin- Liganden (Pinen-N-py Derivate) hergestellt. Die 6’-Brom substituierten Pinen-bpy Derivate stellen dabei geeignete Zwischenstufen für die Synthese von weiteren 6’- substituierten Pinen-bpy Derivate dar. Tetradentate Liganden...

Université de Fribourg

Glycosylphosphatidylinositol membrane anchors in "Saccharomyces cerevisiae" : characterization of proteins involved in side chain modifications

Flury, Isabelle ; Conzelmann, Andreas (Dir.) ; Aebi, Markus (Codir.) ; Puoti, Alessandro (Codir.)

Thèse de doctorat : Université de Fribourg, 2001 ; Nr. 1361.

Die Verankerung von bestimmten Proteinen an der Aussenseite der Plasmamembran mittels eines Glycosylphosphatidylinositol (GPI)-Ankers ist in eukaryontischen Zellen weit verbreitet. Es gibt Hinweise, dass GPI-Anker neben ihrer Funktion als stabiler Anker auch eine wichtige Rolle in der Uebertragung von Signalen und in der Sortierung von Proteinen spielen. Sowohl die Biosynthese des GPI-Ankers als...

Université de Genève

Rigid-rod β-barrel pores as enzyme sensors

Sordé, Nathalie ; Matile, Stefan (Dir.)

Thèse de doctorat : Université de Genève, 2004 ; Sc. 3575.

Université de Lausanne

Replicating adenoviruses targeting tumours with constitutive activation of the Wnt signalling pathway

Fuerer, Christophe ; Iggo, Richard (Dir.) ; Widmer, François (Codir.)

Thèse de doctorat : Université de Lausanne, 2004.

Activation of the Wnt pathway through mutation of the adenomatous polyposis coli and -catenin genes is a hallmark of colon cancer. These mutations lead to constitutive activation of transcription from promoters containing binding sites for Tcf/LEF transcription factors. Tumour-selective replicating oncolytic viruses are promising agents for cancer therapy. They can in principle spread...

Université de Fribourg

The dynamic localization and novel functions of the Ipl1/Aurora protein kinase

Buvelot, Stéphanie ; Conzelmann, Andreas (Dir.)

Thèse de doctorat : Université de Fribourg : 2003 ; no 1400.

Proper chromosome segregation is a crucial event for accurate cell division. Defects in chromosome segregation lead to genetic instability and aneuploidy and are correlated with cancer. The laboratory studies chromosome segregation in the budding yeast Saccharomyces cerevisiae. Since this process is highly conserved among eukaryotes, studies in yeast will provide fundamental understanding of this...

Université de Neuchâtel

Analytical development and traceability in food chemistry : examples of application to Swiss and foreign Emmental cheese = Développement analytique et traçabilité en chimie alimentaire : exemple d'application à des Emmental suisses et étrangers

Pillonel, Laurent ; Tabacchi, Raphaël (Dir.)

Thèse de doctorat : Université de Neuchâtel : 2004 ; 1766.

The current Ph.D. work is divided into four main parts. In the first one, the problematic of volatile compound preconcentration is dealt with to extend the application range of electronic noses (ENs). A review article highlights the advantages of portable equipments such as Solid Phase Micro-Extraction (SPME) and Solid Phase Dynamic Extraction (SPDE). Both showed comparable efficiencies when...

Université de Neuchâtel

Les complexes arène-ruthénium et polyoxométallates : un lien entre la chimie organométallique et la chimie inorganique

Garcia Fidalgo, Eva ; Süss-Fink, Georg (Dir.)

Thèse de doctorat : Université de Neuchâtel : 2001 ; 1588.

The first part of this work refers to the complexes arene-ruthénium. since their discovery in 1967 by Winkhaus and Singer, the dinuclear arene-ruthenium complexes [(n6 -arène)RuCI2]2, erroneously considered as polymers in the beginning, have been widely used in organometallic chemistry. Very often used in synthesis and homogeneous catalysis, they are easily accessible and perfectly air-stable....

Université de Neuchâtel

New Multifunctional Ligands for the Catalytic Carbonylation of Methanol

Thomas, Christophe ; Süss-Fink, Georg (Dir.)

Thèse de doctorat : Université de Neuchâtel : 2002 ; 1638.

The aim of the present work was to synthesize new multifunctional ligands, to study their coordination properties and to exploit their catalytic potential for the carbonylation of methanol. The carbonylation of methanol to give acetic acid is one of the most important homogeneously catalysed industrial processes. The original [Rh(CO)2I2]- catalyst, developed at the Monsanto laboratories, is...