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Université de Fribourg

Towards a photochemical synthesis of peptides

Bochet, Christian G.

In: CHIMIA International Journal for Chemistry, 2013, vol. 67, no. 12, p. 896–898

The laboratory preparation of peptides, once a challenge, is now a standard operation that can be automatised. However, the need for particular protecting groups requiring relatively harsh conditions for their removal (strong acids or bases) and reactive coupling agents can be problematic in specific cases (e.g. in a cell or in a microfluidic device). In this account, we describe our efforts...

Université de Fribourg

Photoinduced acyl transfer

Débieux, Jean-Luc ; Bochet, Christian G.

In: Journal of Physical Organic Chemistry, 2010, p. -

The acylation reaction occupies a central role in biochemistry and organic synthesis. On the one hand, it is by this very reaction that amino acids successively assemble to form peptides and proteins, and on the other hand it is a major synthetic method encompassing esterification, amidation, Friedel-Crafts reaction and many other processes routinely used both at the laboratory and the industrial...