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Université de Neuchâtel

Synthesis, Molecular Structure, and Anticancer Activity of Cationic Arene Ruthenium Metallarectangles

Mattsson, Johan ; Govindaswamy, Padavattan ; Renfrew, Anna K. ; Dyson, Paul J. ; Štěpnička, Petr ; Süss-Fink, Georg ; Therrien, Bruno

In: Organometallics, 2009, vol. 28, no. 15, p. 4350–4357

The cytotoxicities of a new series of cationic metallarectangles have been established in the A2780 ovarian cancer cell line. Interestingly, the large rectangles incorporating 1,2-bis(4-pyridyl)ethylene linkers are ca. 5 times more cytotoxic (IC50 ≤ 6 μM) than the 4,4-bipyridine analogues (IC50 ≥ 30 μM), thus suggesting a correlation between cytotoxicity and the size...

Université de Neuchâtel

Template-Directed Synthesis of Hexanuclear Arene Ruthenium Complexes with Trigonal-Prismatic Architecture Based on 2,4,6-Tris(3-pyridyl)triazine Ligands

Freudenreich, Julien ; Furrer, Julien ; Süss-Fink, Georg ; Therrien, Bruno

In: Organometallics, 2011, vol. 30, no. 5, p. 942–951

Cationic arene ruthenium metalla-prisms of the general formula [Ru6(p-cymene)6(3-tpt)2(OO∩OO)3]6+ (3-tpt = 2,4,6-tris(3-pyridyl)-1,3,5-triazine; OO∩OO = 5,8-dioxido-1,4-naphthoquinonato [1]6+ or 6,11-dioxido-5,12-naphthacenedionato [2]6+) have been obtained from the corresponding...

Université de Neuchâtel

Efficient Oxidation of Cysteine and Glutathione Catalyzed by a Dinuclear Areneruthenium Trithiolato Anticancer Complex

Giannini, Federico ; Furrer, Julien ; Süss-Fink, Georg

In: Inorganic Chemistry, 2011, vol. 50, no. 21, p. 10552–10554

The highly cytotoxic diruthenium complex [(p-MeC6H4Pri)2Ru2(SC6H4-p-Me)3]+ (1), water-soluble as the chloride salt, is shown to efficiently catalyze oxidation of the thiols cysteine and glutathione to give the corresponding disulfides, which may explain its high in vitro...

Université de Neuchâtel

Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers

Schmitt, Frédéric ; Freudenreich, Julien ; Barry, Nicolas P.E. ; Juillerat-Jeanneret, Lucienne ; Süss-Fink, Georg ; Therrien, Bruno

In: Journal of the American Chemical Society (JACS), 2012, vol. 134, no. 2, p. 754-757

Water-soluble metalla-cages were used to deliver hydrophobic porphin molecules to cancer cells. After internalization, the photosensitizer was photoactivated, significantly increasing the cytotoxicity in cells. During the transport, the photosensitizer remains nonreactive to light, offering a new strategy to tackle overall photosensitization, a limitation often encountered in photodynamic...

Université de Neuchâtel

Mesomorphic Metallo-Dendrimers Based on the Metal−Metal Bonded Ru2(CO)4 Sawhorse Unit

Frein, Stéphane ; Auzias, Mathieu ; Sondenecker, Aline ; Vieille-Petit, Ludovic ; Guintchin, Boris ; Maringa, Natacha ; Süss-Fink, Georg ; Barberá, Joaquín ; Deschenaux, Robert

In: Chemistry of Materials, 2008, vol. 20, no. 4, p. 1340-1343

Dinuclear ruthenium complexes containing the stable metal−metal bonded Ru2(CO)4 sawhorse unit with two dendritic carboxylato bridges have been synthesized and characterized. All complexes Ru2(CO)4(O2CR)2L2 (R = R1, R2, R3) containing cyanobiphenyl-based poly(arylester) dendrons of first...

Université de Neuchâtel

Thiolato-Bridged Arene–Ruthenium Complexes: Synthesis, Molecular Structure, Reactivity, and Anticancer Activity of the Dinuclear Complexes [(arene)2Ru2 (SR)2Cl2]

Ibao, Anne-Flore ; Gras, Michaël ; Therrien, Bruno ; Süss-Fink, Georg ; Zava, Olivier ; Dyson, Paul J.

In: European Journal of Inorganic Chemistry, 2012, vol. 2012, no. 9, p. 1531-1535

Treatment of an arene–ruthenium dichloride dimer with thiols RSH to lead to cationic trithiolato complexes of the type [(arene) 2Ru2(SR)3]+ was shown to proceed through the neutral thiolato complexes [(arene)2Ru2(SR)2Cl2], which have been isolated and characterized for arene =...