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Université de Fribourg

Vesicle origami: cuboid phospholipid vesicles formed by template‐free self‐assembly

Neuhaus, Frederik ; Mueller, Dennis ; Tanasescu, Radu ; Balog, Sandor ; Ishikawa, Takashi ; Brezesinski, Gerald ; Zumbuehl,  Andreas

In: Angewandte Chemie International Edition, 2017, vol. 56, no. 23, p. 6515–6518

Phospholipid liposomes are archetypical self-assembled structures. To minimize the surface tension, the vesicles typically are spherical. Deciphering the bilayer code, the basic physical interactions between phospholipids would allow these molecules to be utilized as building blocks for novel, non-spherical structures. A 1,2- diamidophospholipid is presented that self-assembles into a cuboid...