Université de Fribourg

Rapid and sensitive quantification of cell-associated multi-walled carbon nanotubes

Steinmetz, Lukas ; Bourquin, Joel ; Barosova, Hana ; Haeni, Laetitia ; Caldwell, Jessica ; Milosevic, Ana ; Geers, Christoph ; Bonmarin, Mathias ; Taladriz-Blanco, Patricia ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Nanoscale, 2020, vol. 12, no. 33, p. 17362–17372

Evaluating nanomaterial uptake and association by cells is relevant for in vitro studies related to safe-by-design approaches, nanomedicine or applications in photothermal therapy. However, standard analytical techniques are time-consuming, involve complex sample preparation or include labelling of the investigated sample system with e.g. fluorescent dyes. Here, we explore lock-in...

Université de Fribourg

Use of EpiAlveolar lung model to predict fibrotic potential of multiwalled carbon nanotubes

Barosova, Hana ; Maione, Anna G. ; Septiadi, Dedy ; Sharma, Monita ; Haeni, Laetitia ; Balog, Sandor ; O’Connell, Olivia ; Jackson, George R. ; Brown, David ; Clippinger, Amy J. ; Hayden, Patrick ; Petri-Fink, Alke ; Stone, Vicki ; Rothen-Rutishauser, Barbara

In: ACS Nano, 2020, vol. 14, no. 4, p. 3941–3956

Expansion in production and commercial use of nanomaterials increases the potential human exposure during the lifecycle of these materials (production, use, and disposal). Inhalation is a primary route of exposure to nanomaterials; therefore it is critical to assess their potential respiratory hazard. Herein, we developed a three-dimensional alveolar model (EpiAlveolar) consisting of human...

Université de Fribourg

Carbon nanodots: Opportunities and limitations to study their biodistribution at the human lung epithelial tissue barrier

Durantie, Estelle ; Barosova, Hana ; Drasler, Barbara ; Rodriguez-Lorenzo, Laura ; Urban, Dominic A. ; Vanhecke, Dimitri ; Septiadi, Dedy ; Hirschi-Ackermann, Liliane ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Biointerphases, 2018, vol. 13, no. 6, p. 06D404

Inhalation of combustion-derived ultrafine particles (≤0.1 μm) has been found to be associated with pulmonary and cardiovascular diseases. However, correlation of the physicochemical properties of carbon-based particles such as surface charge and agglomeration state with adverse health effects has not yet been established, mainly due to limitations related to the detection of carbon...

Université de Fribourg

Biological response of an in vitro human 3D lung cell model exposed to brake wear debris varies based on brake pad formulation

Barosova, Hana ; Chortarea, Savvina ; Peikertova, Pavlina ; J. D. Clift, Martin ; Petri-Fink, Alke ; Kukutschova, Jana ; Rothen-Rutishauser, Barbara

In: Archives of Toxicology, 2018, vol. 92, no. 7, p. 2339–2351

Wear particles from automotive friction brake pads of various sizes, morphology, and chemical composition are significant contributors towards particulate matter. Knowledge concerning the potential adverse effects following inhalation exposure to brake wear debris is limited. Our aim was, therefore, to generate brake wear particles released from commercial low-metallic and non-asbestos organic...

Université de Fribourg

Characteristics and properties of nano-LiCoO2 synthesized by pre-organized single source precursors: Li-ion diffusivity, electrochemistry and biological assessment

Brog, Jean?Pierre ; Crochet, Aurélien ; Seydoux, Joël ; Clift, Martin J. D. ; Baichette, Benoît ; Maharajan, Sivarajakumar ; Barosova, Hana ; Brodard, Pierre ; Spodaryk, Mariana ; Züttel, Andreas ; Rothen?Rutishauser, Barbara ; Kwon, Nam Hee ; Fromm, Katharina M.

In: Journal of Nanobiotechnology, 2017, vol. 15, p. 58

LiCoO₂ is one of the most used cathode materials in Li-ion batteries. Its conventional synthesis requires high temperature (>800 °C) and long heating time (>24 h) to obtain the micronscale rhombohedral layered high-temperature phase of LiCoO₂ (HT-LCO). Nanoscale HT-LCO is of interest to improve the battery performance as the lithium (Li⁺) ion pathway is expected to be shorter in...