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Lipid nanoparticles biocompatibility and cellular uptake in a 3D human lung model

Magalhães, Joana ; Pinheiro, Marina ; Drasler, Barbara ; Septiadi, Dedy ; Petri-Fink, Alke ; Santos, Susana G ; Rothen-Rutishauser, Barbara ; Reis, Salette

In: Nanomedicine, 2020, vol. 15, no. 3, p. 259–271

Aim: Design nanostructured lipid carriers (NLC) to facilitate drug delivery to tuberculosis-infected areas, exploiting macrophage mannose receptors and assess their uptake in a 3D human lung model. Materials & methods: NLCs and mannosylated-NLCs were synthetized and characterized. Their uptake and biocompatibility were tested in a 3D human lung model. Results: The formulations have...