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    Université de Fribourg

    Immunological response to nitroglycerin-loaded shear-responsive liposomes in vitro and in vivo

    Buscema, Marzia ; Matviykiv, Sofiya ; Mészáros, Tamás ; Gerganova, Gabriela ; Weinberger, Andreas ; Mettal, Ute ; Mueller, Dennis ; Neuhaus, Frederik ; Stalder, Etienne ; Ishikawa, Takashi ; Urbanics, Rudolf ; Saxer, Till ; Pfohl, Thomas ; Szebeni, János ; Zumbuehl, Andreas ; Müller, Bert

    In: Journal of Controlled Release, 2017, vol. 264, no. Supplement C, p. 14–23

    Liposomes formulated from the 1,3-diamidophospholipid Pad-PC-Pad are shear- responsive and thus promising nano-containers to specifically release a vasodilator at stenotic arteries. The recommended preclinical safety tests for therapeutic liposomes of nanometer size include the in vitro assessment of complement activation and the evaluation of the associated risk of complement...