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Ultrathin ceramic membranes as scaffolds for functional cell coculture models on a biomimetic scale

Jud, Corinne ; Ahmed, Sher ; Müller, Loretta ; Kinnear, Calum ; Vanhecke, Dimitri ; Umehara, Yuki ; Frey, Sabine ; Liley, Martha ; Angeloni, Silvia ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: BioResearch Open Access, 2015, vol. 4, no. 1, p. 457–468

Epithelial tissue serves as an interface between biological compartments. Many in vitro epithelial cell models have been developed as an alternative to animal experiments to answer a range of research questions. These in vitro models are grown on permeable two-chamber systems; however, commercially available, polymer-based cell culture inserts are around 10 μm thick. Since the basement...