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Monolayer properties of 1,3-diamidophospholipids

Fedotenko, lllya A. ; Stefaniu, Cristina ; Brezesinski, Gerald ; Zumbuehl, Andreas

In: Langmuir, 2013, vol. 29, no. 30, p. 9428–9435

While nature provides an endless variety of phospholipids presenting hydrolyzable ester linkages for the 1,2-positioned hydrocarbon tails, we designed and synthesized 1,3-diamidophospholipids which contain stable fatty acid amides. These new phospholipids form faceted unilamellar vesicles with mechanosensitive properties. Aiming to understand the mechanism responsible for this behavior at a...