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    Université de Fribourg

    A hydrofluoric acid-free method to dissolve and quantify silica nanoparticles in aqueous and solid matrices

    Bossert, David ; Urban, Dominic A. ; Maceroni, Mattia ; Ackermann-Hirschi, Liliane ; Haeni, Laetitia ; Yajan, Phattadon ; Spuch-Calvar, Miguel ; Rothen-Rutishauser, Barbara ; Rodriguez-Lorenzo, Laura ; Petri-Fink, Alke ; Schwab, Fabienne

    In: Scientific Reports, 2019, vol. 9, no. 1, p. 7938

    As the commercial use of synthetic amorphous silica nanomaterials (SiO2-NPs) increases, their effects on the environment and human health have still not been explored in detail. An often-insurmountable obstacle for SiO2-NP fate and hazard research is the challenging analytics of solid particulate silica species, which involves toxic and corrosive hydrofluoric acid (HF). We therefore developed...

    Université de Fribourg

    Polymer-coated gold nanospheres do not impair the innate immune function of human b lymphocytes in vitro

    Hočevar, Sandra ; Milošević, Ana ; Rodriguez-Lorenzo, Laura ; Ackermann-Hirschi, Liliane ; Mottas, Inès ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Bourquin, Carole ; Clift, Martin James David

    In: ACS Nano, 2019, vol. 13, no. 6, p. 6790–6800

    Gold nanoparticles (GNPs) are intended for use within a variety of biomedical applications due to their physicochemical properties. Although, in general, biocompatibility of GNPs with immune cells such as macrophages and dendritic cells is well established, the impact of GNPs on B lymphocyte immune function remains to be determined. Since B lymphocytes play an important role in health and...

    Université de Fribourg

    Simple and fast evaluation of relaxation parameters of magnetic nanoparticles

    Lemal, Philipp ; Balog, Sandor ; Ackermann-Hirschi, Liliane ; Taladriz-Blanco, Patricia ; Hirt, Ann M. ; Rothen-Rutishauser, Barbara ; Lattuada, Marco ; Petri-Fink, Alke

    In: Journal of Magnetism and Magnetic Materials, 2020, vol. 499, p. 166176

    The efficacy of magnetic hyperthermia treatment depends on the optimal available magnetic nanoparticles (MNPs) that are excited in a given alternating magnetic field and viscosity of the region of interest. In this regard, assessing the relevant relaxation parameters is of upmost importance and could improve the speed of development of efficient applications. Here, we demonstrate how to...