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Université de Fribourg

Taylor dispersion of inorganic nanoparticles and comparison to dynamic light scattering and transmission electron microscopy

A.Urban, Dominic ; M.Milosevic, Ana ; Bossert, David ; Crippa, Federica ; L.Moore, Thomas ; Geers, Christoph ; Balog, Sandor ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Colloid and Interface Science Communications, 2018, vol. 22, p. 29–33

Taylor dispersion analysis (TDA) is an analytical method that has so far mainly been utilized to determine the diffusion coefficient of small molecules, and proteins. Due to increasing interest in nanoscience, some research has been done on the applicability of TDA towards characterizing nanoparticles. This work aims to expand this knowledge and give insight into the range for which TDA can...

Université de Fribourg

Translocation of gold nanoparticles across the lung epithelial tissue barrier: Combining in vitro and in silico methods to substitute in vivo experiments

Bachler, Gerald ; Losert, Sabrina ; Umehara, Yuki ; Goetz, Natalie von ; Rodriguez-Lorenzo, Laura ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Hungerbuehler, Konrad

In: Particle and Fibre Toxicology, 2015, vol. 12, no. 1, p. 18

The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into the systemic circulation. Thus great efforts are currently being made to determine adverse health effects associated with inhalation of NPs. However, to date very little is known about factors that determine the pulmonary translocation of NPs and their subsequent distribution to secondary...

Université de Fribourg

Dynamic depolarized light scattering of small round plasmonic nanoparticles: When imperfection is only perfect

Balog, Sandor ; Rodriguez-Lorenzo, Laura ; Monnier, Christophe A. ; Michen, Benjamin ; Obiols-Rabasa, Marc ; Casal-Dujat, Lucia ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke ; Schurtenberger, Peter

In: The Journal of Physical Chemistry C, 2014, vol. 118, no. 31, p. 17968–17974

Although small round gold nanoparticles (Au NPs) possess only a small degree of shape anisotropy, they support localized surface plasmon resonances and exhibit intrinsic optical anisotropy. These inherent features promote depolarized light scattering, whose temporal fluctuations carry information about rotational Brownian dynamics, and thus can be used to describe the size distribution of...

Université de Fribourg

Use of EpiAlveolar lung model to predict fibrotic potential of multiwalled carbon nanotubes

Barosova, Hana ; Maione, Anna G. ; Septiadi, Dedy ; Sharma, Monita ; Haeni, Laetitia ; Balog, Sandor ; O’Connell, Olivia ; Jackson, George R. ; Brown, David ; Clippinger, Amy J. ; Hayden, Patrick ; Petri-Fink, Alke ; Stone, Vicki ; Rothen-Rutishauser, Barbara

In: ACS Nano, 2020, vol. 14, no. 4, p. 3941–3956

Expansion in production and commercial use of nanomaterials increases the potential human exposure during the lifecycle of these materials (production, use, and disposal). Inhalation is a primary route of exposure to nanomaterials; therefore it is critical to assess their potential respiratory hazard. Herein, we developed a three-dimensional alveolar model (EpiAlveolar) consisting of human...

Université de Fribourg

Biological response of an in vitro human 3D lung cell model exposed to brake wear debris varies based on brake pad formulation

Barosova, Hana ; Chortarea, Savvina ; Peikertova, Pavlina ; J. D. Clift, Martin ; Petri-Fink, Alke ; Kukutschova, Jana ; Rothen-Rutishauser, Barbara

In: Archives of Toxicology, 2018, vol. 92, no. 7, p. 2339–2351

Wear particles from automotive friction brake pads of various sizes, morphology, and chemical composition are significant contributors towards particulate matter. Knowledge concerning the potential adverse effects following inhalation exposure to brake wear debris is limited. Our aim was, therefore, to generate brake wear particles released from commercial low-metallic and non-asbestos organic...

Université de Fribourg

Mimicking the chemistry of natural eumelanin synthesis: the ke sequence in polypeptides and in proteins allows for a specific control of nanosized functional polydopamine formation

Bergtold, Camille ; Hauser, Daniel ; Alain Chaumont ; El Yakhlifi, Salima ; Mateescu, Mihaela ; Meyer, Florent ; Metz-Boutigue, Marie-Hélène ; Benoît Frisch ; Schaaf, Pierre ; Ihiawakrim, Dris ; Ersen, Ovidiu ; Monnier, Christophe A. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Ball, Vincent

In: Biomacromolecules, 2018, vol. 19, no. 9, p. 3693–3704

The oxidation of dopamine and of other catecholamines leads to the formation of conformal films on the surface of all known materials and to the formation of a precipitate in solution. In some cases, it has been shown that the addition of additives in the dopamine solution, like certain surfactants or polymers, polyelectrolytes, and certain proteins, allows to get polydopamine nanoparticles...

Université de Fribourg

Assessment of lung cell toxicity of various gasoline engine exhausts using a versatile in vitro exposure system

Bisig, Christoph ; Comte, Pierre ; Güdel, Martin ; Czerwinski, Jan ; Mayer, Andreas ; Müller, Loretta ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Environmental Pollution, 2018, vol. 235, p. 263–271

Adverse effect studies of gasoline exhaust are scarce, even though gasoline direct injection (GDI) vehicles can emit a high number of particles. The aim of this study was to conduct an in vitro hazard assessment of different GDI exhausts using two different cell culture models mimicking the human airway. In addition to gasoline particle filters (GPF), the effects of two lubrication oils with...

Université de Fribourg

Spatial SPION localization in liposome membranes

Bonnaud, Cécile ; Vanhecke, Dimitri ; Demurtas, Davide ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: IEEE Transactions on Magnetics, 2012, vol. 49, no. 1, p. 166-171

Nanocarriers, including liposomes, offer great opportunities for targeted and controlled therapy. The development in this field has led to a large panel of drug delivery systems, which can be classified into 3 different nanovector generations. However, the success of such smart materials requires the control of a large variety of properties and parameters. Unfortunately, characterization at the...

Université de Fribourg

A hydrofluoric acid-free method to dissolve and quantify silica nanoparticles in aqueous and solid matrices

Bossert, David ; Urban, Dominic A. ; Maceroni, Mattia ; Ackermann-Hirschi, Liliane ; Haeni, Laetitia ; Yajan, Phattadon ; Spuch-Calvar, Miguel ; Rothen-Rutishauser, Barbara ; Rodriguez-Lorenzo, Laura ; Petri-Fink, Alke ; Schwab, Fabienne

In: Scientific Reports, 2019, vol. 9, no. 1, p. 7938

As the commercial use of synthetic amorphous silica nanomaterials (SiO2-NPs) increases, their effects on the environment and human health have still not been explored in detail. An often-insurmountable obstacle for SiO2-NP fate and hazard research is the challenging analytics of solid particulate silica species, which involves toxic and corrosive hydrofluoric acid (HF). We therefore developed...

Université de Fribourg

Speckle-visibility spectroscopy of depolarized dynamic light scattering

Bossert, David ; Natterodt, Jens ; Urban, Dominic A. ; Weder, Christoph ; Petri-Fink, Alke

In: The Journal of Physical Chemistry B, 2017, vol. 121, no. 33, p. 7999–8007

We show that the statistical analysis of photon counts in depolarized dynamic light scattering experiments allows for the accurate characterization of the rotational Brownian dynamics of particles. Unlike photon correlation spectroscopy, the technique is accurate even at low temporal resolution and enables discontinuous data acquisition, which offers several advantages. To demonstrate the...