Université de Neuchâtel

Increasing the size of metalla-assemblies to target the EPR-effect of tumors and solid cancers

Mannancherril, Vidya ; Therrien, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2019.

Cancer, a malignant disease, is one of the leading causes of mortality and morbidity among humans. However, selective targeting of cancerous tissue remains challenging. The enhanced permeability and retention effect (EPR-effect), a naturally occurring phenomenon in solid cancerous tissue, is a suitable treatment pathway to selectively target cancerous tissues, whereas healthy tissue remains...

Université de Neuchâtel

Synthesis, characterization and exploration of the catalytic, supramolecular and biological applications of dinuclear complexes

Johnpeter, Justin Paul Raj ; Therrien, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2013.

The work presented in this thesis involves the synthesis and characterization of dinuclear ruthenium, rhodium and iridium complexes. The catalytic, supramolecular and biological applications of these dinuclear complexes will be discussed. In the first part, the synthesis of sawhorse-type diruthenium tetracarbonyl complexes and their catalytic applications in the supercritical carbon dioxide...