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Increasing the size of metalla-assemblies to target the EPR-effect of tumors and solid cancers

Mannancherril, Vidya ; Therrien, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2019.

Cancer, a malignant disease, is one of the leading causes of mortality and morbidity among humans. However, selective targeting of cancerous tissue remains challenging. The enhanced permeability and retention effect (EPR-effect), a naturally occurring phenomenon in solid cancerous tissue, is a suitable treatment pathway to selectively target cancerous tissues, whereas healthy tissue remains...