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Human epithelial cells in vitro – Are they an advantageous tool to help understand the nanomaterial-biological barrier interaction?

Rothen-Rutishauser, Barbara ; Clift, Martin J.D. ; Jud, Corinne ; Fink, Alke ; Wick, Peter

In: Euro Nanotox Letters, 2012, vol. 4, no. 01, p. 1-20

The human body can be exposed to nanomaterials through a variety of different routes. As nanomaterials get in contact with the skin, the gastrointestinal tract, and the respiratory tract, these biological compartments are acting as barriers to the passage of nano-sized materials into the organism. These structural and functional barriers are provided by the epithelia serving as an interface...

Spatial SPION localization in liposome membranes

Bonnaud, Cécile ; Vanhecke, Dimitri ; Demurtas, Davide ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: IEEE Transactions on Magnetics, 2012, vol. 49, no. 1, p. 166-171

Nanocarriers, including liposomes, offer great opportunities for targeted and controlled therapy. The development in this field has led to a large panel of drug delivery systems, which can be classified into 3 different nanovector generations. However, the success of such smart materials requires the control of a large variety of properties and parameters. Unfortunately, characterization at the...

Nanoparticles and cells: an interdisciplinary approach

Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Chimia, 2012, vol. 66, no. 3, p. 104-109

In this article we present an overview of some of our research in the field of nanoscience. By combining two different scientific backgrounds (chemistry and biology), we investigate nanoparticle-cell interactions from different angles. This requires an interdisciplinary approach involving material synthesis and characterization, cell biology (biochemistry) and microscopy. In particular, we...

Influence of serum supplemented cell culture medium on colloidal stability of polymer coated iron oxide and polystyrene nanoparticles with impact on cell interactions in vitro

Hirsch, Vera ; Salaklang, Jatuporn ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: IEEE Transactions on Magnetics, 2012, vol. 49, no. 1, p. 402-407

When nanoparticles interact with cells, the possible cellular responses to the particles depend on an array of parameters, in both particle and biological aspects. On the one hand, the physicochemical properties of the particles (e.g., material, size, shape, and surface charge) are known to play a key role in particle-cell interactions. On the other hand, it has been shown that prior to coming...

Amino covalent binding approach on iron oxide nanoparticle surface: toward biological applications

Griffete, Nébéwia ; Clift, Martin J.D. ; Lamouri, Aazdine ; Digigow, Reinaldo G. ; Mihut, Adriana M. ; Fink, Alke ; Rothen-Rutishauser, Barbara ; Dietsch, Hervé

In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2012, p. -

We report on the synthesis and the surface modification of different types of magnetic iron oxide particles by developing an original process based on diazonium salts chemistry. Particles were first coated with amino groups and then subjected to polyethylene glycol (PEG) surface modification. They were subsequently characterized by Transmission electron microscopy, infrared spectroscopy,...

Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles

Mahmoudi, Morteza ; Hofmann, Heinrich ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Chemical Reviews, 2012, vol. 112, no. 4, p. 2323–2338