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Université de Fribourg

Unexpected Decoupling of Stretching and Bending Modes in Protein Gels

Gibaud, Thomas ; Zaccone, Alessio ; Gado, Emanuela Del ; Trappe, Véronique ; Schurtenberger, Peter

In: Physical Review Letters, 2013, vol. 110, no. 5, p. 058303

We show that gels formed by arrested spinodal decomposition of protein solutions exhibit elastic properties in two distinct frequency domains, both elastic moduli exhibiting a remarkably strong dependence on volume fraction. Considering the large difference between the protein size and the characteristic length of the network we model the gels as porous media and show that the high and low...

Université de Fribourg

Phase separation and dynamical arrest for particles interacting with mixed potentials—the case of globular proteins revisited

Gibaud, Thomas ; Cardinaux, Frédéric ; Bergenholtz, Johan ; Stradner, Anna ; Schurtenberger, Peter

In: Soft Matter, 2011, vol. 7, no. 3, p. 857

We examine the applicability of the extended law of corresponding states (ELCS) to equilibrium and non equilibrium features of the state diagram of the globular protein lysozyme. We provide compelling evidence that the ELCS correctly reproduces the location of the binodal for different ionic strengths, but fails in describing the location of the arrest line. We subsequently use Mode Coupling...

Université de Fribourg

A closer look at arrested spinodal decomposition in protein solutions

Gibaud, Thomas ; Schurtenberger, Peter

In: Journal of Physics: Condensed Matter, 2009, vol. 21, p. 322201

Concentrated aqueous solutions of the protein lysozyme undergo a liquid–solid transition upon a temperature quench into the unstable spinodal region below a characteristic arrest temperature of Tf = 15 °C. We use video microscopy and ultra-small angle light scattering in order to investigate the arrested structures as a function of initial concentration, quench temperature...

Université de Fribourg

A simple patchy colloid model for the phase behavior of lysozyme dispersions

Gögelein, Christoph ; Nägele, Gerhard ; Tuinier, Remco ; Gibaud, Thomas ; Stradner, Anna ; Schurtenberger, Peter

In: The Journal of Chemical Physics, 2008, vol. 129, no. 8, p. 085102

We propose a minimal model for spherical proteins with aeolotopic pair interactions to describe the equilibrium phase behavior of lysozyme. The repulsive screened Coulomb interactions between the particles are taken into account assuming that the net charges are smeared out homogeneously over the spherical protein surfaces. We incorporate attractive surface patches, with the interactions between...

Université de Fribourg

Interplay between spinodal decomposition and glass formation in proteins exhibiting short-range attractions

Cardinaux, Frédéric ; Gibaud, Thomas ; Stradner, Anna ; Schurtenberger, Peter

In: Physical Review Letters, 2007, vol. 99, no. 11, p. 118301

We investigate the competition between spinodal decomposition and dynamical arrest using aqueous solutions of the globular protein lysozyme as a model system for colloids with short-range attractions. We show that quenches below a temperature Ta lead to gel formation as a result of a local arrest of the protein-dense phase during spinodal decomposition. The rheological...