Affiner les résultats

Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK

Langmesser, Sonja ; Tallone, Tiziano ; Bordon, Alain ; Rusconi, Sandro ; Albrecht, Urs

In: BMC Molecular Biology, 2008, vol. 9, p. 41

Background: Circadian oscillation of clock-controlled gene expression is mainly regulated at the transcriptional level. Heterodimers of CLOCK and BMAL1 act as activators of target gene transcription; however, interactions of PER and CRY proteins with the heterodimer abolish its transcriptional activation capacity. PER and CRY are therefore referred to as negative regulators of the circadian...