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Université de Fribourg

New insights into the mechanisms of organ-specific breast cancer metastasis

Lorusso, Girieca ; Rüegg, Curzio

In: Seminars in Cancer Biology, 2012, p. -

Despite the substantial advances obtained in the treatment of localized malignancies, metastatic disease still lacks effective treatment and remains the primary cause of cancer mortality, including in breast cancer. Thus, in order to improve the survival of cancer patients it is necessary to effectively improve prevention or treatment of metastasis. To achieve this goal, complementary strategies...

Université de Fribourg

Concepts of metastasis in flux: the stromal progression model

Sleeman, Jonathan P. ; Christofori, Gerhard ; Fodde, Riccardo ; Collard, John G. ; Berx, Geert ; Decraene, Charles ; Rüegg, Curzio

In: Seminars in Cancer Biology, 2012, p. -

The ability of tumor cells to leave a primary tumor, to disseminate through the body, and to ultimately seed new secondary tumors is universally agreed to be the basis for metastasis formation. An accurate description of the cellular and molecular mechanisms that underlie this multistep process would greatly facilitate the rational development of therapies that effectively allow metastatic...