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    Université de Fribourg

    Targeting breast cancer cells by MRS1477, a positive allosteric modulator of TRPV1 channels

    Nazıroğlu, Mustafa ; Çiğ, Bilal ; Blum, Walter ; Vizler, Csaba ; Buhala, Andrea ; Marton, Annamária ; Katona, Róbert ; Jósvay, Katalin ; Schwaller, Beat ; Oláh, Zoltán ; Pecze, László

    In: PLOS ONE, 2017, vol. 12, no. 6, p. e0179950

    There is convincing epidemiological and experimental evidence that capsaicin, a potent natural transient receptor potential cation channel vanilloid member 1 (TRPV1) agonist, has anticancer activity. However, capsaicin cannot be given systemically in large doses, because of its induction of acute pain and neurological inflammation. MRS1477, a dihydropyridine derivative acts as a positive...

    Université de Fribourg

    Menthol evokes Ca2+ signals and induces oxidative stress independently of the presence of TRPM8 (menthol) receptor in cancer cells

    Nazıroğlu, Mustafa ; Blum, Walter ; Jósvay, Katalin ; Çiğ, Bilal ; Henzi, Thomas ; Oláh, Zoltán ; Vizler, Csaba ; Schwaller, Beat ; Pecze, László

    In: Redox Biology, 2018, vol. 14, p. 439–449

    Menthol is a naturally occurring monoterpene alcohol possessing remarkable biological properties including antipruritic, analgesic, antiseptic, anti-inflammatory and cooling effects. Here, we examined the menthol-evoked Ca2+ signals in breast and prostate cancer cell lines. The effect of menthol (50–500µM) was predicted to be mediated by the transient receptor potential ion channel...

    Université de Fribourg

    Albumin evokes Ca 2+ -induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin

    Nazıroğlu, Mustafa ; Çiğ, Bilal ; Yazğan, Yener ; Schwaerzer, Gerburg K. ; Theilig, Franziska ; Pecze, László

    In: Scientific Reports, 2019, vol. 9, no. 1, p. 1–16

    In proteinuric nephropathies of chronic kidney disease, the epithelial cells of the nephron including the collecting duct are exposed to high concentrations of luminal albumin. Albumin is taken up from collecting duct cells by endocytosis causing excessive reactive oxygen species (ROS) production and a proinflammatory response. Curcumin used in the traditional medicine possesses...

    Université de Fribourg

    Nanoparticles as potential clinical therapeutic agents in Alzheimer’s disease: focus on selenium nanoparticles

    Nazıroğlu, Mustafa ; Muhamad, Salina ; Pecze, Laszlo

    In: Expert Review of Clinical Pharmacology, 2017, vol. 10, no. 7, p. 773–782

    In etiology of Alzheimer’s disease (AD), involvement of amyloid β (Aβ) plaque accumulation and oxidative stress in the brain have important roles. Several nanoparticles such as titanium dioxide, silica dioxide, silver and zinc oxide have been experimentally using for treatment of neurological disease. In the last decade, there has been a great interest on combination of antioxidant...