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Albumin evokes Ca 2+ -induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin

Nazıroğlu, Mustafa ; Çiğ, Bilal ; Yazğan, Yener ; Schwaerzer, Gerburg K. ; Theilig, Franziska ; Pecze, László

In: Scientific Reports, 2019, vol. 9, no. 1, p. 1–16

In proteinuric nephropathies of chronic kidney disease, the epithelial cells of the nephron including the collecting duct are exposed to high concentrations of luminal albumin. Albumin is taken up from collecting duct cells by endocytosis causing excessive reactive oxygen species (ROS) production and a proinflammatory response. Curcumin used in the traditional medicine possesses...