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Université de Fribourg

Repetitive activation of the corticospinal pathway by means of rTMS may reduce the efficiency of corticomotoneuronal synapses

Taube, Wolfgang ; Leukel, Christian ; Nielsen, Jens Bo ; Lundbye-Jensen, Jesper

In: Cerebral Cortex, 2014, p. -

Low-frequency rTMS applied to the primary motor cortex (M1) may produce depression of motor-evoked potentials (MEPs). This depression is commonly assumed to reflect changes in cortical circuits. However, little is known about rTMS-induced effects on subcortical circuits. Therefore, the present study aimed to clarify whether rTMS influences corticospinal transmission by altering the efficiency of...

Université de Fribourg

Cross-limb interference during motor learning

Lauber, Benedikt ; Lundbye-Jensen, Jesper ; Keller, Martin ; Gollhofer, Albert ; Taube, Wolfgang ; Leukel, Christian

In: PLoS ONE, 2013, vol. 8, no. 12, p. e81038

It is well known that following skill learning, improvements in motor performance may transfer to the untrained contralateral limb. It is also well known that retention of a newly learned task A can be degraded when learning a competing task B that takes place directly after learning A. Here we investigate if this interference effect can also be observed in the limb contralateral to the trained...

Université de Fribourg

The effect of balance training on cervical sensorimotor function and neck pain

Beinert, Konstantin ; Taube, Wolfgang

In: Journal of Motor Behavior, 2013, vol. 45, no. 3, p. 271–278

The authors’ aim was to evaluate the effect of balance training on cervical joint position sense in people with subclinical neck pain. Thirty-four participants were randomly assigned to balance training or to stay active. Sensorimotor function was determined before and after 5 weeks of training by assessing the ability to reproduce the neutral head position and a predefined rotated head...

Université de Fribourg

Specific interpretation of augmented feedback changes motor performance and cortical processing

Lauber, Benedikt ; Keller, Martin ; Leukel, Christian ; Gollhofer, Albert ; Taube, Wolfgang

In: Experimental Brain Research, 2013, p. -

It is well established that the presence of external feedback, also termed augmented feedback, can be used to improve performance of a motor task. The present study aimed to elucidate whether differential interpretation of the external feedback signal influences the time to task failure of a sustained submaximal contraction and modulates motor cortical activity. In Experiment 1, subjects had to...

Université de Fribourg

Subconscious visual cues during movement execution allow correct online choice reactions

Leukel, Christian ; Lundbye-Jensen, Jesper ; Christensen, Mark Schram ; Gollhofer, Albert ; Nielsen, Jens Bo ; Taube, Wolfgang

In: PLoS ONE, 2012, vol. 7, no. 9, p. e44496

Part of the sensory information is processed by our central nervous system without conscious perception. Subconscious processing has been shown to be capable of triggering motor reactions. In the present study, we asked the question whether visual information, which is not consciously perceived, could influence decision-making in a choice reaction task. Ten healthy subjects (28±5 years) executed...

Université de Fribourg

How neurons make us jump: the neural control of stretch-Shortening cycle movements

Taube, Wolfgang ; Leukel, Christian ; Gollhofer, Albert

In: Exercise and Sport Sciences Reviews, 2012, vol. 40, no. 2, p. 106–115

How can the human central nervous system (CNS) control complex jumping movements task- and context-specifically? This review highlights the complex interaction of multiple hierarchical levels of the CNS, which work together to enable stretch-shortening cycle contractions composed of activity resulting from feedforward (preprogrammed) and feedback (reflex) loops.

Université de Fribourg

Time to task failure and motor cortical activity depend on the type of feedback in visuomotor tasks

Lauber, Benedikt ; Leukel, Christian ; Gollhofer, Albert ; Taube, Wolfgang

In: PLoS ONE, 2012, vol. 7, no. 3, p. e32433

The present study aimed to elucidate whether the type of feedback influences the performance and the motor cortical activity when executing identical visuomotor tasks. For this purpose, time to task failure was measured during position- and force-controlled muscular contractions. Subjects received either visual feedback about the force produced by pressing a force transducer or about the actual...

Université de Fribourg

Pathway-specific plasticity in the human spinal cord

Leukel, Christian ; Taube, Wolfgang ; Beck, Sandra ; Schubert, Martin

In: European Journal of Neuroscience, 2012, p. -

The aim of the present study was to artificially induce plasticity in the human spinal cord and evaluate whether this plasticity is pathway specific. For this purpose, a technique called paired associative stimulation (PAS) was applied. Volleys evoked by transcranial magnetic stimulation over the primary motor cortex and peripheral nerve stimulation of the nervus tibialis in the popliteal fossa...

Université de Fribourg

Evidence that the cortical motor command for the initiation of dynamic plantarflexion consists of excitation followed by inhibition

Taube, Wolfgang ; Lundbye-Jensen, Jesper ; Schubert, Martin ; Gollhofer, Albert ; Leukel, Christian

In: PLoS ONE, 2011, vol. 6, no. 10, p. e25657

At the onset of dynamic movements excitation of the motor cortex (M1) is spatially restricted to areas representing the involved muscles whereas adjacent areas are inhibited. The current study elucidates whether the cortical motor command for dynamic contractions is also restricted to a certain population of cortical neurons responsible for the fast corticospinal projections. Therefore,...

Université de Fribourg

Short-term pressure induced suppression of the short latency response - a new methodology for investigating stretch reflexes

Leukel, Christian ; Lundbye-Jensen, Jesper ; Gruber, Markus ; Zuur, Abraham T. ; Gollhofer, Albert ; Taube, Wolfgang

In: Journal of Applied Physiology, 2009///doi:10.1152/japplphysiol.00301.2009

During experiments involving ischemic nerve block we noticed that the short latency response (SLR) of evoked stretches in m. soleus decreased immediately following inflation of a pneumatic cuff surrounding the lower leg. The present study aimed to investigate this short-term effect of pressure application in more detail. 58 healthy subjects were divided into 7 protocols. Unilateral stretches were...