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Université de Fribourg

Issues in continuous 24-H core body temperature monitoring in humans using an ingestible capsule telemetric sensor

Monnard, Cathriona R. ; Fares, Elie-Jacques ; Calonne, Julie ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre ; Durrer, Dominique ; Schutz, Yves ; Dulloo, Abdul G.

In: Frontiers in Endocrinology, 2017, vol. 8, p. -

Background: There is increasing interest in the use of pill-sized ingestible capsule telemetric sensors for assessing core body temperature (Tc) as a potential indicator of variability in metabolic efficiency and thrifty metabolic traits. The aim of this study was to investigate the feasibility and accuracy of measuring Tc using the CorTemp® system.Methods: Tc was measured over an average of 20...

Université de Fribourg

Bias in food intake reporting in children and adolescents with type 1 diabetes: the role of body size, age and gender

Maffeis, Claudio ; Schutz, Yves ; Fornari, Elena ; Marigliano, Marco ; Tomasselli, Francesca ; Tommasi, Mara ; Chini, Veronica ; Morandi, Anita

In: Pediatric Diabetes, 2017, vol. 18, no. 3, p. 213–221

An assessment of total daily energy intake is helpful in planning the overall treatment of children with type 1 diabetes (T1D). However, energy intake misreporting may hinder nutritional intervention.Aims: To assess the plausibility of energy intake reporting and the potential role of gender, body mass index (BMI) z-score (z-BMI), disease duration and insulin requirement in energy intake...

Université de Fribourg

Passive and active roles of fat-free mass in the control of energy intake and body composition regulation

Dulloo, Abdul G. ; Jacquet, Jean ; Miles-Chan, Jennifer L ; Schutz, Yves

In: European Journal of Clinical Nutrition, 2017, vol. 71, no. 3, p. 353–357

While putative feedback signals arising from adipose tissue are commonly assumed to provide the molecular links between the body’s long-term energy requirements and energy intake, the available evidence suggests that the lean body or fat-free mass (FFM) also plays a role in the drive to eat. A distinction must, however, be made between a ‘passive’ role of FFM in driving energy intake,...

Université de Fribourg

Isometric thermogenesis at rest and during movement: a neglected variable in energy expenditure and obesity predisposition

Dulloo, Abdul G. ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre ; Schutz, Yves

In: Obesity Reviews, 2017, vol. 18, no. S1, p. 56–64

Isometric thermogenesis as applied to human energy expenditure refers to heat production resulting from increased muscle tension. While most physical activities consist of both dynamic and static (isometric) muscle actions, the isometric component is very often essential for the optimal performance of dynamic work given its role in coordinating posture during standing, walking and most...

Université de Fribourg

Body composition-derived BMI cut-offs for overweight and obesity in Indians and Creoles of Mauritius: comparison with Caucasians

Hunma, S ; Ramuth, H ; Miles-Chan, Jennifer L. ; Schutz, Yves ; Montani, Jean-Pierre ; Joonas, N ; Dulloo, Abdul G.

In: International Journal of Obesity, 2016, vol. 40, no. 12, p. 1906–1914

Global estimates of overweight and obesity prevalence are based on the World Health Organisation (WHO) body mass index (BMI) cut-off values of 25 and 30 kg m⁻², respectively. To validate these BMI cut-offs for adiposity in the island population of Mauritius, we assessed the relationship between BMI and measured body fat mass in this population according to gender and...

Université de Fribourg

Energy expenditure and substrate oxidation in response to side-alternating whole body vibration across three commonly-used vibration frequencies

Fares, Elie-Jacques ; Charrière, Nathalie ; Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G. ; Miles-Chan, Jennifer L.

In: PLOS ONE, 2016, vol. 11, no. 3, p. e0151552

There is increasing recognition about the importance of enhancing energy expenditure (EE) for weight control through increases in low-intensity physical activities comparable with daily life (1.5–4 METS). Whole-body vibration (WBV) increases EE modestly and could present both a useful adjuvant for obesity management and tool for metabolic phenotyping. However, it is unclear whether a...

Université de Fribourg

Fasting substrate oxidation at rest assessed by indirect calorimetry: is prior dietary macronutrient level and composition a confounder?

Miles-Chan, Jennifer L. ; Dulloo, Abdul G. ; Schutz, Yves

In: International Journal of Obesity, 2015, p. -

Indirect calorimetry, the measurement of O₂ consumption and CO₂ production, constitutes an invaluable tool as the most common method for analyzing whole-body energy expenditure, and also provides an index of the nature of macronutrient substrate oxidation—namely, carbohydrate (CHO) versus fat oxidation. The latter constitutes a key etiological factor in obesity as this condition can only...

Université de Fribourg

Impact des ultrasons diffus combinés au travail musculaire sur plaque vibrante sur la modification de la composition corporelle de femmes modérément obèses

Hafiz, S. ; Durrer, D. ; Schutz, Yves

In: Obésité, 2014, p. 1–7

Objectives: To study, in obese subjects, the effect of diffuse ultrasound application in the abdominal area combined to muscular work on a vibrating platform. This dual method aims at accelerating the mobilisation of adipose tissue.Methods: 40 sedentary obese women, 18 to 55 years old, with a BMI ≥30 kg/m2 and ≤40 kg/m2 were randomized into 3 groups. 1) A control group (CONTR, n=13), 2) a...

Université de Fribourg

Heterogeneity in the energy cost of posture maintenance during standing relative to sitting: phenotyping according to magnitude and time-Course

Miles-Chan, Jennifer L. ; Sarafian, Delphine ; Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G.

In: PLoS ONE, 2013, vol. 8, no. 5, p. e65827

Background: Reducing sitting-time may decrease risk of disease and increase life-span. In the search for approaches to reduce sitting-time, research often compares sitting to standing and ambulation, but the energetic cost of standing alone versus sitting is equivocal, with large variation in reported mean values (0% to > 20% increase in energy expenditure (EE) during standing).Objective: To...

Université de Fribourg

Adaptive thermogenesis in human body weight regulation: more of a concept than a measurable entity?

Dulloo, Abdul G. ; Jacquet, Jean ; Montani, Jean-Pierre ; Schutz, Yves

In: Obesity Reviews, 2012, vol. 13, no. S2, p. 105–121

According to Lavoisier, ‘Life is combustion’. But to what extent humans adapt to changes in food intake through adaptive thermogenesis – by turning down the rate of heat production during energy deficit (so as to conserve energy) or turning it up during overnutrition (so as to dissipate excess calories) – has been one of the most controversial issues in nutritional sciences over the past...