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Yeast growth selection system for the identification of cell-active inhibitors of human cytomegalovirus protease

Cottier, Valérie ; Müller, Fritz (Dir.)

Thèse de doctorat : Université de Fribourg, 2006 ; no 1501.

Human cytomegalovirus (HCMV) is one of the most common opportunistic infective agents in immunocompromised individuals, such as AIDS patients and organ transplant recipients, and causes the most frequent congenital infection in humans. Existing antiviral treatments are limited by severe drawbacks, i.e. poor bioavailability, toxicity and limited effectiveness mainly due to the development of drug...