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    2 results 1
    Université de Fribourg

    MAGI1 mediates eNOS activation and NO production in endothelial cells in response to fluid shear stress

    Ghimire, Kedar ; Zaric, Jelena ; Alday-Parejo, Begoña ; Seebach, Jochen ; Bousquenaud, Mélanie ; Stalin, Jimmy ; Bieler, Grégory ; Schnittler, Hans-Joachim ; Rüegg, Curzio

    In: Cells, 2019, vol. 8, no. 5, p. 388

    Fluid shear stress stimulates endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production through multiple kinases, including protein kinase A (PKA), AMP-activated protein kinase (AMPK), AKT and Ca2+/calmodulin-dependent protein kinase II (CaMKII). Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an adaptor protein that...

    Université de Fribourg

    The matricellular protein CYR61 interferes with normal pancreatic islets architecture and promotes pancreatic neuroendocrine tumor progression

    Huang, Yu-Ting ; Lan, Qiang ; Ponsonnet, Lionel ; Blanquet, Marisa ; Christofori, Gerhard ; Zaric, Jelena ; Rüegg, Curzio

    In: Oncotarget, 2015, vol. 7, no. 2, p. 1663–1674

    The significance of matricellular proteins during development and cancer progression is widely recognized. However, how these proteins actively contribute to physiological development and pathological cancer progression is only partially elucidated. In this study, we investigated the role of the matricellular protein Cysteine-rich 61 (CYR61) in pancreatic islet development and carcinogenesis....

    2 results 1