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Université de Fribourg

Nanoparticle polydispersity can strongly affect in vitro dose

Rodriguez-Lorenzo, Laura ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke ; Balog, Sandor

In: Particle & Particle Systems Characterization, 2015, vol. 32, no. 3, p. 321–333

When nanomaterials meet the biological world, the cellular interaction of nanoparticles is routinely assessed in in vitro systems. Establishing dose–response relationships requires that the dose of nanoparticles delivered to the cell is accurate and precise. Nanoparticles as such or coated with high molecular-weight compounds are rarely uniform and the influence of heterogeneity, including...