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Université de Fribourg

How inhibition relates to impulsivity after moderate to severe traumatic brain injury

Rochat, Lucien ; Beni, Catia ; Annoni, Jean-Marie ; Vuadens, Philippe ; Linden, Martial Van der

In: Journal of the International Neuropsychological Society, 2013, vol. 19, no. 08, p. 890–898

Impulsive behaviors and poor inhibition performances are frequently described in patients with traumatic brain injury (TBI). However, few studies have examined impulsivity and associated inhibition impairments in these patients. Twenty-eight patients with moderate to severe TBI and 27 matched controls performed a stop- signal task designed to assess prepotent response inhibition (the ability...

Université de Fribourg

Impairment of both languages in late bilinguals with dementia of the Alzheimer type

Manchon, Mélanie ; Buetler, Karin ; Colombo, Françoise ; Spierer, Lucas ; Assal, Frédéric ; Annoni, Jean-Marie

In: Bilingualism: Language and Cognition, 2014, vol. 18, no. 01, p. 90–100

Neuropsychological theories raise the question if in late bilinguals with dementia of the Alzheimer type (DAT), the second language (L2) may be more impaired than the first (L1). We compared language performance in different tasks of oral comprehension (semantic and syntactic) and production (naming, repetition and fluency) in L1 and L2 in a group of 13 late proficient bilinguals wit DAT...

Université de Fribourg

inter- and intrahemispheric dissociations in ideomotor apraxia : a large-Scale lesion–symptom mapping study in subacute brain-damaged patients

Manuel, Aurelie L. ; Radman, Narges ; Mesot, Delphine ; Chouiter, Leila ; Clarke, Stephanie ; Annoni, Jean-Marie ; Spierer, Lucas

In: Cerebral Cortex, 2012, vol. 23, no. 12, p. 2781-2789

Pantomimes of object use require accurate representations of movements and a selection of the most task-relevant gestures. Prominent models of praxis, corroborated by functional neuroimaging studies, predict a critical role for left parietal cortices in pantomime and advance that these areas store representations of tool use. In contrast, lesion data points to the involvement of left inferior...

Université de Fribourg

Investigating post-stroke fatigue: An individual participant data meta-analysis

B.Cumming, Toby ; Yeo, Ai Beng ; Marquez, Jodie ; Churilov, Leonid ; Annoni, Jean-Marie ; Badaru, Umaru ; Ghotbi, Nastaran ; Harbison, Joe ; Kwakkel, Gert ; Lerdal, Anners ; Mills, Roger ; Naess, Halvor ; Nyland, Harald ; Schmid, Arlene ; Tang, Wai Kwong ; Tseng, Benjamin ; Port, Ingridvan de ; Mead, Gillian ; English, Coralie

In: Journal of Psychosomatic Research, 2018, vol. 113, p. 107–112

The prevalence of post-stroke fatigue differs widely across studies, and reasons for such divergence are unclear. We aimed to collate individual data on post-stroke fatigue from multiple studies to facilitate high-powered meta-analysis, thus increasing our understanding of this complex phenomenon.Methods: We conducted an Individual Participant Data (IPD) meta-analysis on post-stroke fatigue...

Université de Fribourg

Jagged1 is altered in alzheimer’s disease and regulates spatial memory processing

Marathe, Swananda ; Jaquet, Muriel ; Annoni, Jean-Marie ; Alberi, Lavinia

In: Frontiers in Cellular Neuroscience, 2017, vol. 11, p. -

Notch signaling plays an instrumental role in hippocampus-dependent memory formation and recent evidence indicates a displacement of Notch1 and a reduction its activity in hippocampal and cortical neurons from Alzheimer's disease (AD) patients. As Notch activation depends on ligand availability, we investigated whether Jagged1 expression was altered in brain specimen of AD patients. We found...

Université de Fribourg

Language and syntactic impairment following stroke in late bilingual aphasics

Tschirren, Muriel ; Laganaro, Marina ; Michel, Patrik ; Martory, Marie-Dominique ; Di Pietro, Marie ; Abutalebi, Jubin ; Annoni, Jean-Marie

In: Brain and Language, 2011, vol. 119, no. 3, p. 238-242

Purpose :Bilingual aphasia generally affects both languages. However, the age of acquisition of the second language (L2) seems to play a role in the anatomo-functional correlation of the syntactical/grammatical processes, thus potentially influencing the L2 syntactic impairment following a stroke. The present study aims to analyze the influence of late age of acquisition of the L2 on syntactic...

Université de Fribourg

Language context modulates reading route: an electrical neuroimaging study

Buetler, Karin A. ; Rodríguez, Diego de León ; Laganaro, Marina ; Müri, René ; Spierer, Lucas ; Annoni, Jean-Marie

In: Frontiers in Human Neuroscience, 2014, vol. 8, p. article 83

Introduction: The orthographic depth hypothesis (Katz and Feldman, 1983) posits that different reading routes are engaged depending on the type of grapheme/phoneme correspondence of the language being read. Shallow orthographies with consistent grapheme/phoneme correspondences favor encoding via non-lexical pathways, where each grapheme is sequentially mapped to its corresponding phoneme. In...

Université de Fribourg

Language specificity of lexical-phonological therapy in bilingual aphasia: A clinical and electrophysiological study

Radman, Narges ; Spierer, Lucas ; Laganaro, Marina ; Annoni, Jean-Marie ; Colombo, Françoise

In: Neuropsychological Rehabilitation, 2016, vol. 26, no. 4, p. 532–557

Based on findings for overlapping representations of bilingual people's first (L1) and second (L2) languages, unilingual therapies of bilingual aphasia have been proposed to benefit the untrained language. However, the generalisation patterns of intra- and cross-language and phonological therapy and their neural bases remain unclear. We tested whether the effects of an intensive...

Université de Fribourg

Long-term effects of cannabis on brain structure

Battistella, Giovanni ; Fornari, Eleonora ; Annoni, Jean-Marie ; Chtioui, Haithem ; Dao, Kim ; Fabritius, Marie ; Favrat, Bernard ; Mall, Jean-Frédéric ; Maeder, Philippe ; Giroud, Christian

In: Neuropsychopharmacology, 2014, p. -

The dose-dependent toxicity of the main psychoactive component of cannabis in brain regions rich in cannabinoid CB1 receptors is well known in animal studies. However, research in humans does not show common findings across studies regarding the brain regions that are affected after long-term exposure to cannabis. In the present study, we investigate (using Voxel-based Morphometry) gray matter...

Université de Fribourg

The modulation of reading strategies by language opacity in early bilinguals: an eye movement study

De León Rodríguez, Diego ; Buetler, C,, Karin A. ; Eggenberger, Noëmi ; Preisig, Basil C. ; Schumacher, Rahel ; Laganaro, Marina ; Nyffeler, Thomas ; Annoni, Jean-Marie ; Müri, René M.

In: Bilingualism: Language and Cognition, 2016, vol. 19, no. 3, p. 567–577

Converging evidences from eye movement experiments indicate that linguistic contexts influence reading strategies. However, the question of whether different linguistic contexts modulate eye movements during reading in the same bilingual individuals remains unresolved. We examined reading strategies in a transparent (German) and an opaque (French) language of early, highly proficient...