Haute Ecole d'Ingénierie

Développement de la mobilité ionique pour la détection des sites de sumoylation des protéines = Identification of SUMOylation Sites using High-Field Asymmetric Waveform Ion Mobility (FAIMS) coupled to a Linear Ion Trap/Orbitrap Mass Spectrometer

Pfammatter, Sibylle ; Kalman, Franka (Dir.)

Mémoire de bachelor : Haute Ecole d'Ingénierie, 2014.

SUMOylation is a post-translational modification of proteins that is involved in different cellular processes including mitosis, DNA replication and transcription. However its detection by liquid chromatography coupled to mass spectrometry (LC-MS) can be challenging due to its low abundance and dynamic regulation. High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) helps in...