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Université de Fribourg

Circadian rhythms in murine pups develop in absence of a functional maternal circadian clock

Jud, Corinne ; Albrecht, Urs

In: Journal of Biological Rhythms, 2006, vol. 21, no. 2, p. 149-154

A genetic approach was used to investigate whether the emergence of circadian rhythms in murine pups is dependent on a functional maternal clock. Arrhythmic females bearing either the mPer1Brdm1/Per2Brdm1 or mPer2Brdm1/Cry1-/- double-mutant genotype were crossed with wild-type males under constant darkness. The heterozygous offspring have the genetic...