Thèse de doctorat : Università della Svizzera italiana, 2009 ; 2009INFO002.
Performance and high-availability are the crucial factors in the development of nowadays distributed database systems. Both of these challenges are commonly addressed by means of the same technique, database replication. The overall throughput of the system is increased by leveraging parallel computation on different sites, and in case of replica failures, availability is improved by...
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In: Disability & Rehabilitation, 2008, vol. 30, no. 14, p. 1063 - 1078
Purpose. To illustrate the conceptualization and development of a research institution from the comprehensive perspective based on the integrative model of functioning provided by the World Health Organization's (WHO) International Classification of Functioning, Disability and Health (ICF). The newly founded research institution Swiss Paraplegic Research which focuses on the comprehensive study...
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In: Surgical Endoscopy, 2008, vol. 22, no. 4, p. 901-906
Background: Nowadays, the laparoscopic approach represents the gold standard for a wide range of various basic and advanced procedures. To reduce the learning curve in advanced laparoscopic surgery, the search for new teaching tools is of utmost importance. Our experiences with a new teaching tool to train advanced laparoscopic procedures are reported. Methods: Hands-on training courses in...
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Thèse de doctorat : Université de Fribourg, 2008.
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In: Neuroscience, 2007, vol. 150, no. 3, p. 537-546
To determine whether Toxoplasma gondii infection could modify biological phenomena associated with brain ischemia, we investigated the effect of permanent middle cerebral artery occlusion (MCAO) on neuronal survival, inflammation and redox state in chronically infected mice. Infected animals showed a 40% to 50% decrease of infarct size compared with non-infected littermates 1, 4 and 14 days after...
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In: The American Journal of Human Genetics, 2008, vol. 83, no. 1, p. 43-52
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In: Communicative & Integrative Biology, 2008, vol. 1, no. 1, p. 1-3
Over many years evidence accumulated that circadian rhythms are related to psychiatric disorders.1-3 However, a mechanistic relationship between the circadian clock and mood related behaviors remained enigmatic. Now, we have reported that monoamine oxidase A (MAOA), a mitochondrial enzyme degrading catecholamines including dopamine, is regulated by components of the circadian clock .4...
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In: ISESCO Science and Technology Vision, 2007, vol. 3, no. 3, p. 49-53
Les zones urbaines sont caractérisées par une grande concentration d'activités économiques et sociales. La conséquence est que les activités résidentielles, commerciales ou industrielles exigent un énorme taux de consommation de ressources. Cela peut aboutir à des problèmes liés à l'environnement. En plus de l'épuisement des ressources fossiles dans un avenir proche, il y a des...
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Thèse de doctorat : Université de Fribourg, 2006.
Research on language acquisition has shown that language development depends on language experience during early childhood. Early acquisition of one as opposed to two languages should therefore influence the development of language capabilities. Various psycholinguistic studies have provided support for this idea. The impact of early second language acquisition on the establishment of the...
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In this paper, the system is viewed as a construction based on the actors’ cognitive and social interactions. The system is the result of multiple – actor sense making (Weick 1995), but at the same time it orients social sense making. In this process each actor’s point of view is a representation of both the system and the context perceived as pertinent by the actor. In other words, the...
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