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Université de Genève

Management of sigmoid volvulus in Eritrea

Mehari, Habteab ; Soravia, Claudio (Dir.)

Thèse de doctorat : Université de Genève, 2002 ; Méd. 10269.

Université de Fribourg

The tip60 HAT-complex is recruited to chromatin by the transcription factors E2F and Myc

Taubert, Stefan ; Conzelmann, Andreas (Dir.)

Thèse de doctorat : Université de Fribourg, 2003 ; no 1409.

The oncogenic transcription factors E2F and Myc bind to specific DNA sequences at distinct times during the G1 phase of the mammalian cell cycle, and regulate transcription of a plethora of target genes. E2F and Myc associate with TRRAP, a subunit of distinct macromolecular complexes that contain the histone acetyltransferases (HATs) Gcn5/PCAF or Tip60. During the course of my thesis I...

Université de Fribourg

EMuds : adaptation in text-based virtual worlds

Robert, Antony ; Courant, Michèle (Dir.)

Thèse de doctorat : Université de Fribourg, 1999 ; no 1272.

This thesis introduces a methodological approach to artificial agent design. In an attempt to solve the symbol grounding problem of artificial intelligence, a new theoretical perspective on the agent-environment relation is explored and experimentation is led to motivate this methodology. From the original idea that in order to ground an agent in an environment, the agent’s representation...

Université de Fribourg

Towards active network management with "Ecomobile", an ecosystem-inspired mobile agent middleware : design, implementation, simulation and application to optical networks

Rossier-Ramuz, Daniel ; Hirsbrunner, Beat (Dir.) ; Scheurer, Rudolf (Codir.)

Thèse de doctorat : Université de Fribourg, 2002 ; no 1392.

The future multi-layer optical networks based on wavelength division multiplexing technology will lead to the creation of new value-added optical services, which is bound to transform the traditional passive transport network into an active and intelligent transport layer. The successful deployment of these complex networking services and the possibility of subjecting them to a dynamic control,...

Université de Fribourg

The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation

Solinas, Giovanni ; Summermatter, Serge ; Mainieri, Davide ; Gubler, Marcel ; Pirola, Luciano ; Wymann, Matthias P. ; Rusconi, Sandro ; Montani, Jean-Pierre ; Seydoux, Josiane

In: FEBS Letters, 2004, vol. 577 (3), p. 539-544

We report here studies that integrate data of respiration rate from mouse skeletal muscle in response to leptin and pharmacological interference with intermediary metabolism, together with assays for phosphatidylinositol 3-kinase (PI3K) and AMP-activated protein kinase (AMPK). Our results suggest that the direct effect of leptin in stimulating thermogenesis in skeletal muscle is mediated by...

Université de Fribourg

Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity

Dulloo, Abdul G. ; Gubler, Marcel ; Montani, Jean-Pierre ; Seydoux, Josiane ; Solinas, Giovanni

In: International Journal of Obesity, 2004, vol. 28 (Suppl. 4), p. S29-S37

Life is a combustion, but how the major fuel substrates that sustain human life compete and interact with each other for combustion has been at the epicenter of research into the pathogenesis of insulin resistance ever since Randle proposed a 'glucose-fatty acid cycle' in 1963. Since then, several features of a mutual interaction that is characterized by both reciprocality and dependency between...