In: International Journal of Antimicrobial Agents, 2014, vol. 43, no. 2, p. 195–196
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In: Future Microbiology, 2013, vol. 9, no. 1, p. 33–41
The impact of carbapenemase production among clinically significant Gram-negative rods is becoming a major medical issue. To date, Acinetobacter baumannii has been considered as a final recipient of carbapenemase genes (imipenemase, Verona metallo-β-lactamase, Guiana extended-spectrum β-lactamase and Klebsiella pneumonia carbapenemase types) from Enterobacteriaceae and ...
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In: Antimicrobial Agents and Chemotherapy, 2015, p. AAC.04450–14
Resistance to ß-lactams is constantly increasing, due to the emergence of totally new enzymes, but also to the evolution of pre-existing ß-lactamases. GES-1 is a clinically-relevant extended-spectrum β-lactamase (ESBL) hydrolyzing penicillins and broad-spectrum cephalosporins, but sparing monobactams and carbapenems. However, several GES-1 variants (i.e. GES-2 and GES-5) previously identified...
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In: Journal of Antimicrobial Chemotherapy, 2016, vol. 71, no. 8, p. 2318-2320
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In: Eurosurveillance, 2013, vol. 18, no. 31, p. 20547
We report the first outbreak of carbapenem-resistant NDM-1-producing Acinetobacter baumannii in Europe, in a French intensive-care unit in January to May 2013. The index patient was transferred from Algeria and led to the infection/colonisation of five additional patients. Concurrently, another imported case from Algeria was identified. The seven isolates were genetically indistinguishable,...
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In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, no. 10, p. 2787-2791
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In: BioMed Research International, 2014, vol. 2014, p. e249856
The emergence of one of the most recently described carbapenemases, namely, the New Delhi metallo-lactamase (NDM-1), constitutes a critical and growingly important medical issue. This resistance trait compromises the efficacy of almost all lactams (except aztreonam), including the last resort carbapenems. Therapeutical options may remain limited mostly to colistin, tigecycline, and fosfomycin....
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In: Journal of Clinical Microbiology, 2014, p. JCM.00594–14
Multidrug-resistant Acinetobacter baumannii isolates, and particularly carbapenemase-producing isolates, are increasingly reported worldwide. The biochemically-based Carba NP test, extensively validated for detection of carbapenemase producers among Enterobacteriaceae and Pseudomonas spp., has been modified for the detection of carbapenemase production in Acinetobacter spp. A collection of 151...
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In: Antimicrobial Agents and Chemotherapy, 2014, vol. 58, no. 2, p. 1269–1269
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In: Antimicrobial Agents and Chemotherapy, 2014, vol. 58, no. 4, p. 2441-2445
A prospective survey was conducted on 862 Enterobacteriaceae with reduced susceptibility to carbapenems. The Carba NP test, UV spectrophotometry and DNA microarray were used for detecting carbapenemase producers, and results compared to PCR and sequencing. The 172 carbapenemase producers were detected using the Carba NP test and UV spectrophotometry whereas DNA microarray failed to detect IMI...
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