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Université de Fribourg

About the usefulness of contact precautions for carriers of extended-spectrum beta-lactamase-producing Escherichia coli

Zahar, Jean-Ralph ; Poirel, Laurent ; Dupont, Claire ; Fortineau, Nicolas ; Nassif, Xavier ; Nordmann, Patrice

In: BMC Infectious Diseases, 2015, vol. 15, p. 512

Extended-spectrum β-lactamases producing Escherichia coli (ESBL-E) are increasingly identified in health care facilities. As previously done for the control of methicillin-resistant Staphylococcus aureus, many hospitals have established screening strategies for early identification of patients being carriers of ESBL producers in general and ESBL-E in particular, and have implemented contact...

Université de Fribourg

Bloodstream infections caused by Pseudomonas spp.; how to detect carbapenemase producers directly from positive blood cultures ?

Dortet, Laurent ; Boulanger, Anne ; Poirel, Laurent ; Nordmann, Patrice

In: Journal of Clinical Microbiology, 2014, vol. 52, no. 4, p. 1269–1273

The Carba NP test has been evaluated to detect carbapenemase-producing Pseudomonas spp. directly from blood cultures. This rapid and cost-effective test permits an early identification of carbapenemase-producing Pseudomonas spp. directly from blood cultures with excellent sensitivity and specificity. Results may be useful in particular for guiding the first-line therapy and epidemiological...

Université de Fribourg

CarbAcineto NP test for rapid detection of carbapenemase-producers in Acinetobacter spp.

Dortet, Laurent ; Poirel, Laurent ; Errera, Caroline ; Nordmann, Patrice

In: Journal of Clinical Microbiology, 2014, p. JCM.00594–14

Multidrug-resistant Acinetobacter baumannii isolates, and particularly carbapenemase-producing isolates, are increasingly reported worldwide. The biochemically-based Carba NP test, extensively validated for detection of carbapenemase producers among Enterobacteriaceae and Pseudomonas spp., has been modified for the detection of carbapenemase production in Acinetobacter spp. A collection of 151...

Université de Fribourg

Carbapenemase-producing enterobacteriaceae in Europe: a survey among national experts from 39 countries, february 2013

Glasner, C. ; Albiger, B. ; Buist, G. ; Tambić Andrašević, A. ; Canton, R. ; Carmeli, Y. ; Friedrich, A. W. ; Giske, C. G. ; Glupczynski, Y. ; Gniadkowski, M. ; Livermore, D. M. ; Nordmann, Patrice ; Poirel, Laurent ; Rossolini, G. M. ; Seifert, H. ; Vatopoulos, A. ; Walsh, T. ; Woodford, N. ; Donker, T. ; Monnet, D. L. ; Grundmann, H. ; group, the European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) working

In: Euro Surveillance, 2013, vol. 18, no. 28, p. 20525

The spread of carbapenemase-producing Enterobacteriaceae (CPE) is a threat to healthcare delivery, although its extent differs substantially from country to country. In February 2013, national experts from 39 European countries were invited to self-assess the current epidemiological situation of CPE in their country. Information about national management of CPE was also reported. The results...

Université de Fribourg

Carbapenemase-producing Enterobacteriaceae: Overview of a major public health challenge = Entérobactéries et carbapénémases : bilan et enjeux d’un problème de santé publique majeur

Nordmann, Patrice

In: Médecine et Maladies Infectieuses, 2014, vol. 44, no. 2, p. 51–56

Bacterial resistance to antibiotics has become a major source of concern for public health. Enterobacteriaceae are among the most common human pathogens, causing community-acquired as well as hospital-acquired infections. Carbapenem-resistant Enterobacteriaceae have been increasingly reported worldwide since their first identification more than 20 years ago. Three main classes of carbapenemases...

Université de Fribourg

The carbapenemase threat in the animal world : the wrong culprit

Poirel, Laurent ; Stephan, Roger ; Perreten, Vincent ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2014, vol. 69, no. 7, p. 2007-2008

We read with great interest two recent publications dealing with the same topic, i.e. the public health risk related to the occurrence of acquired carbapenemase-producing Gram-negative species in the animal world and the environment.1,2 Woodford et al.1 highlight the series of reports of carbapenemases found either in bacteria isolated from non-human sources or in Salmonella enterica subsp....

Consortium of Swiss Academic Libraries

The carbapenemase threat in the animal world: the wrong culprit

Poirel, Laurent ; Stephan, Roger ; Perreten, Vincent ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2014, vol. 69, no. 7, p. 2007-2008

Université de Fribourg

Comparative evaluation of a novel chromogenic medium (chromID OXA-48) for detection of OXA-48 producing Enterobacteriaceae

Girlich, Delphine ; Anglade, Claire ; Zambardi, Gilles ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2014, vol. 77, no. 4, p. 296–300

Comparative evaluation of the recently developed chromogenic culture medium chromID OXA-48 (bioMérieux) with chromID CARBA (bioMérieux) and SUPERCARBA showed that chromID OXA-48 and SUPERCARBA media have the highest sensitivity for detection of OXA-48 producing Enterobacteriaceae (91% and 93%) comparatively to chromID CARBA (21 %). The chromID OXA-48 has the highest specificity, with 100%, as...