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Università della Svizzera italiana

MicroRNAs in hematopoietic development

Montagner, Sara ; Dehó, Lorenzo ; Monticelli, Silvia

In: BMC immunology, 2014, vol. 15, p. 14

Background: MicroRNAs (miRNAs) are short non-coding RNAs involved in the posttranscriptional regulation of a wide range of biological processes. By binding to complementary sequences on target messenger RNAs, they trigger translational repression and degradation of the target, eventually resulting in reduced protein output. MiRNA-dependent regulation of protein translation is a very widespread...