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Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity

Toso, Alberto ; Revandkar, Ajinkya ; Di Mitri, Diletta ; Guccini, Ilaria ; Proietti, Michele ; Sarti, Manuela ; Pinton, Sandra ; Zhang, Jiangwen ; Kalathur, Madhuri ; Civenni, Gianluca ; Jarrossay, David ; Montani, Erica ; Marini, Camilla ; Garcia-Escudero, Ramon ; Scanziani, Eugenio ; Grassi, Fabio ; Pandolfi, Pier Paolo ; Catapano, Carlo V. ; Alimonti, Andrea

In: Cell reports, 2014, vol. 9, no. 1, p. 75-89

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

Genini, Davide ; Brambilla, Lara ; Laurini, Erik ; Merulla, Jessica ; Civenni, Gianluca ; Pandit, Shusil ; D'Antuono, Rocco ; Perez, Laurent ; Levy, David E. ; Pricl, Sabrina ; Carbone, Giuseppina M. ; Catapano, Carlo V.

In: Proceedings of the national academy of sciences of the United States of America, 2017, vol. 114, no. 25, p. E4924-E4933

In addition to its canonical role in nuclear transcription, signal transducer and activator of transcription 3 (STAT3) is emerging as an important regulator of mitochondrial function. Here, we demonstrate that a novel inhibitor that binds with high affinity to the STAT3 SH2 domain triggers a complex cascade of events initiated by interference with mitochondrial STAT3 (mSTAT3). The...