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Université de Fribourg

Hematopoietic regulation by catecholamines

Togni, Mauro ; Dreyer, Jean-Luc (Dir.)

Thèse de doctorat : Université de Fribourg, 2000 ; no 1284.

Université de Fribourg

The tip60 HAT-complex is recruited to chromatin by the transcription factors E2F and Myc

Taubert, Stefan ; Conzelmann, Andreas (Dir.)

Thèse de doctorat : Université de Fribourg, 2003 ; no 1409.

The oncogenic transcription factors E2F and Myc bind to specific DNA sequences at distinct times during the G1 phase of the mammalian cell cycle, and regulate transcription of a plethora of target genes. E2F and Myc associate with TRRAP, a subunit of distinct macromolecular complexes that contain the histone acetyltransferases (HATs) Gcn5/PCAF or Tip60. During the course of my thesis I...

Université de Fribourg

Interaction of Per and Cry genes in the mammalian circadian clock

Oster, Henrik ; Albrecht, Urs (Dir.)

Thèse de doctorat : Université de Fribourg, 2002 ; Nr. 1396.

To cope with the daily changes in their environment, in organisms, from cyanobacteria to humans, endogenous clocks have evolved that anticipate these changes and synchronize physiology and behavior accordingly. In mammals, the central circadian pacemaker is located in the suprachiasmatic nuclei (SCN) of the hypothalamus. From there subordinated cellular clocks in the peripheral organs are...

Université de Fribourg

Automatic software configuration : a model for service provisioning in dynamic and heterogeneous environments

Schubiger-Banz, Simon ; Hisbrunner, Béat (Dir.)

Thèse de doctorat : Université de Fribourg, 2002 ; no 1393.

This dissertation addresses three fundamental problems, which have to be handled in application domains like ubiquitous computing and Web services. The three problems heterogeneity, static configuration, and dynamic configuration are not only considered to persist during the near future but to increase, as similar application domains will emerge. The heterogeneity problem is defined and examples...

Université de Fribourg

EMuds : adaptation in text-based virtual worlds

Robert, Antony ; Courant, Michèle (Dir.)

Thèse de doctorat : Université de Fribourg, 1999 ; no 1272.

This thesis introduces a methodological approach to artificial agent design. In an attempt to solve the symbol grounding problem of artificial intelligence, a new theoretical perspective on the agent-environment relation is explored and experimentation is led to motivate this methodology. From the original idea that in order to ground an agent in an environment, the agent’s representation...

Université de Fribourg

Towards active network management with "Ecomobile", an ecosystem-inspired mobile agent middleware : design, implementation, simulation and application to optical networks

Rossier-Ramuz, Daniel ; Hirsbrunner, Beat (Dir.) ; Scheurer, Rudolf (Codir.)

Thèse de doctorat : Université de Fribourg, 2002 ; no 1392.

The future multi-layer optical networks based on wavelength division multiplexing technology will lead to the creation of new value-added optical services, which is bound to transform the traditional passive transport network into an active and intelligent transport layer. The successful deployment of these complex networking services and the possibility of subjecting them to a dynamic control,...

Université de Fribourg

Optimierung automatisierter Kompaktlager in Entwurf und Steuerung

Klinkert, Andreas ; Gröflin, Heinz (Dir.) ; Liebling, Thomas M. (Codir.)

Thèse de doctorat : Université de Fribourg, 2001 ; N° 1353.

Die vorliegende Dissertation beschäftigt sich mit der Optimierung automatisierter Kompaktlager in der Phase des Entwurfs und bei der Entwicklung der Lagersteuerung. Automatisierte Kompaktlager bilden in der modernen Lagertechnik eine platzsparende Alternative zu herkömmlichen Zeilenregallagern. Ein automatisiertes Kompaktlager besteht aus mehreren Lagerebenen, welche gegliedert sind in parallel...

Université de Fribourg

Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity

Dulloo, Abdul G. ; Gubler, Marcel ; Montani, Jean-Pierre ; Seydoux, Josiane ; Solinas, Giovanni

In: International Journal of Obesity, 2004, vol. 28 (Suppl. 4), p. S29-S37

Life is a combustion, but how the major fuel substrates that sustain human life compete and interact with each other for combustion has been at the epicenter of research into the pathogenesis of insulin resistance ever since Randle proposed a 'glucose-fatty acid cycle' in 1963. Since then, several features of a mutual interaction that is characterized by both reciprocality and dependency between...

Université de Fribourg

Une approche uniforme pour la reconnaissance de la structure physique de documents composites fondée sur l'analyse des espaces

Azokly, Antoine Sourou ; Ingold, Rolf (Dir.) ; Stamon, Georges (Codir.)

Thèse de doctorat : Université de Fribourg : 1995 ; 1105.

Nous présentons dans cette thèse une approche d’analyse uniforme pour la reconnaissance de la structure physique des documents à contenu varié. Après une introduction à la problématique traitée dans cette thèse, nous présentons une synthèse des traitements usuels dans le domaine de la reconnaissance des documents. Dans cette synthèse, nous présentons aussi les structures usuelles...

Université de Fribourg

Argumentation systems and belief functions

Lehmann, Norbert ; Kohlas, Jürg (Dir.) ; Moral, Serafin (Codir.)

Thèse de doctorat : Université de Fribourg : 2001 ; 1340.

Uncertain knowledge can be represented in the framework of argumentation systems. In this framework, uncertainty is expressed using so-called assumptions. Depending on the setting of the assumptions, a given hypothesis of interest can be proved or falsified. The main goal of assumption-based reasoning is to determine the set of all supporting arguments for a given hypothesis. Such a supporting...