Université de Neuchâtel

Thiolato-bridged arene ruthenium complexes as anticancer agents

Stíbal, David ; Süss-Fink, Georg (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2015.

Cancer is a major cause of morbidity and mortality in today’s world, affecting populations in all countries and all regions. Although no drug or treatment able to cure cancer in all of its forms and variations was found so far, the clinical advancements of 20th and 21st century provided a number of effective drugs for specific types of cancers and had a significant effect...

Université de Neuchâtel

From anticancer complexes to photoswitchable assemblies : new approaches in the design and synthesis of arene ruthenium species

Cheminel, Thomas ; Therrien, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2016.

The aim of the present thesis was to explore new approaches in the design and synthesis of new arene ruthenium species. This class of organometallic compounds has been the subject of much attention in the recent years due to their interesting properties in various fields, such as medicinal chemistry or supramolecular chemistry. In order to achieve this goal, this work was divided into two...

Université de Neuchâtel

Insight into the rules dictating the formation of arene ruthenium metalla-assemblies

Garci, Amine ; Therrien, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2015.

The self-assembly process is a natural phenomenon with the ability to organize biological systems. Its development by chemists as a synthetic process allowed the formation of esthetical structures as well as highly complex supramolecular systems with remarkable biological functions. Since 1990, metal directed self-assembly strategy has largely contributed to the design and synthesis of discrete...

Université de Neuchâtel

Propriétés mésomorphes ou biologiques d'assemblages dendritiques et métallodendritiques

Pitto-Barry, Anaïs ; Deschenaux, Robert (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2012 ; 2256.

The aim of this thesis is to combine metals and dendrimers to obtain mesomorphic or biological properties. The design of metamaterials from gold nanoparticles is still a challenge as the spatial organisation is difficult to control. Thus, the combination of gold nanoparticles with liquid-crystalline dendrimers is a way to explore the organisation of such systems in mesophases. We...

Université de Neuchâtel

Metallic ruthenium nanoparticles derived from arene ruthenium complexes : synthesis, characterization and applications

Khan, Farooq-Ahmad ; Süss-Fink, Georg (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2012 ; 2247.

The present work deals with the preparation of ruthenium nanoparticles using an organometallic approach. In the first part, the synthesis of ruthenium nanoparticles stabilized by mesogenic isonicotinic ester ligands is presented. We have been interested in the use of long-chain isonicotinic esters as lipohilic components in order to increase the anticancer activity of arene ruthenium...

Université de Neuchâtel

Arene Ruthenium Assemblies for Biological Applications : From Carceplex to Host-Guest Metalla-Cages

Barry, Nicolas ; Süss-Fink, Georg (Dir.) ; Therrien, Bruno (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2011 ; 2192.

Since the development of supramolecular chemistry in the 1980s more and more discrete molecular objects have been synthesised. In this research area metals play a key role. Indeed, the coordination-driven self-assembly allows a directional-bonding approach that organises the different building blocks into supramolecular objects according to the coordination modes of the transition metal....