Thèse de doctorat : Université de Fribourg, 2001 ; Nr. 1323.
Membrane anchoring of ceil surface proteins by means of glycosyl phosphatidyl-inositol (GPI) anchors is ubiquitous among eucaryotes. GPI anchoring is essential for yeast viability. In mammals, GPI anchoring is not required at the cellular level, but plays an important role in ceil to ceil and ceil to environment interactions which for example are critical during embryogenesis. GPI proteins can...
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Thèse de doctorat : Université de Fribourg, 2000 ; nr. 1321.
Apoptosis is a key event occurring in living organisms. In order to maintain tissue homeostasis, a comparable number of cells have to die to compensate for the cells produced by mitosis. However in many diseases this mechanism is altered. Once a malignancy is established, the conventional approach is to treat cells with drugs able to induce apoptosis. Although the execution of apoptosis is a...
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Thèse de doctorat : Université de Fribourg, 2002 ; no 1391.
The present research focuses on the ceramic products of the two Final Neolithic dwelling settlements of Portalban and St. Blaise, Western Switzerland, relative to the Old and Medium Auvernier-cordé (2700 – 2400 BC) cultural groups. These two important sites are inserted in the sequence of the Three Lakes Region (Neuchâtel, Bienne and Morat), which includes a complete stratigraphy ranging from...
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Thèse de doctorat : Université de Fribourg, 2000 ; no 1307.
Tenascin-R (TN-R) is a glycosylated brain extracellular matrix protein (BECM; Zamze et al., 1999) restricted to the central nervous system (Pesheva et al., 1989; Rathjen et al., 1991; Weber et al., 1999). A special feature of TN-R, and some of its known ligands, is their accumulation around certain sub-populations of neurones, forming perineuronal nets of extracellular matrix (PNEMs; Wintergerst...
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Thèse de doctorat : Université de Fribourg, 2001 ; Nr. 1361.
In eukaryotic cells, a subset of proteins is attached to the outer leaflet of the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. Apart from providing stable membrane anchorage, GPI anchors are thought to be associated with other functions, such as signal transduction and protein targeting. The biosynthesis of the GPI anchor and its transfer to proteins is highly conserved in...
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Thèse de doctorat : Université de Fribourg : 2003 ; no 1400.
Proper chromosome segregation is a crucial event for accurate cell division. Defects in chromosome segregation lead to genetic instability and aneuploidy and are correlated with cancer. The laboratory studies chromosome segregation in the budding yeast Saccharomyces cerevisiae. Since this process is highly conserved among eukaryotes, studies in yeast will provide fundamental understanding of this...
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Thèse de doctorat : Université de Fribourg : 2002.
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Thèse de doctorat : Université de Fribourg : 2002 ; no 1388.
The biocompatibility of materials in implant or biosensor fields strongly depends on first interactions occurring between a given surface and a biological environment. It is well-known that a living body brought into contact with a surface will induce protein adsorption, which creates the interface, on which proteins or cells will adsorb. The interactions can be influenced by modifying the...
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Thèse de doctorat : Université de Fribourg : 2000 ; Nr. 1328.
Human gene therapy can be defined as the directed transfer of exogenous genes or other nucleotide sequences into somatic cells, for the purpose of preventing, correcting or healing various diseases. This novel approach to the therapy of human disorders is based on the realization that many previous medical treatments have usually been directed at the consequences of causative defects or at...
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Thèse de doctorat : Université de Fribourg : 2004.
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